Topical Application of Dehydroxymethylepoxyquinomicin Improves Allergic Inflammation via NF-κB Inhibition

    July 2010 in “ Journal of Allergy and Clinical Immunology ”
    Asuka Hamasaka, Naoya Yoshioka, Riichiro Abe, Satoshi Kishino, Kazuo Umezawa, Michitaka Ozaki, Satoru Todo, Hiroshi Shimizu
    TLDR A new cream, DHMEQ, reduces allergic skin inflammation effectively.
    The study demonstrated that dehydroxymethylepoxyquinomicin (DHMEQ), a novel NF-κB inhibitor, effectively reduced allergic inflammation in atopic dermatitis (AD) model mice. DHMEQ suppressed NF-κB activity, reduced inflammatory cytokine expression, and inhibited Langerhans cell migration. Topical application of DHMEQ significantly improved the severity of AD-like skin lesions, showing efficacy comparable to tacrolimus and betamethasone. These findings suggested that DHMEQ could be a promising therapeutic option for AD, especially for cases unresponsive to conventional treatments.
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