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Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

Testosterone and its metabolites have varied effects on different body systems, especially during puberty.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Short-term testosterone therapy in women seems safe with few mild side effects, but long-term effects need more research.

Enzyme replacement therapy may help alleviate symptoms in complex cases like this.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

Niosomes improve minoxidil skin penetration for hair loss treatment.

The hair follicle pathway significantly affects how easily water-loving chemicals pass through the skin.

Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

The document concludes that there is no agreed-upon best method for measuring drug delivery within hair follicles and more research is needed to validate current techniques.

Hair follicles may soon be used more for targeted and systemic drug delivery.

Environmental pollutants can damage hair health and cause hair loss.

Hormones affect skin aging and fat distribution, and treatments can help, but only minoxidil is proven for female hair loss.

Minoxidil inside tiny particles can deliver more drug to hair follicles, potentially improving treatment for hair loss.

Hair follicles are important for drug delivery through the skin, but better methods are needed to understand and improve this process.

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

Propylene glycol and ethanol increase finasteride skin absorption, sodium lauryl sulfate doesn't.

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

Testosterone therapy for postmenopausal women appears safe and may protect against heart disease, but requires constant monitoring and more research for long-term effects.

Testosterone improves mood and thinking skills; finasteride has no effect.