Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

This study found that the deletion of soluble epoxide hydrolase (sEH) in mice altered the hair follicle cycle and increased hair growth through effects on hair follicle stem and matrix cells.

This study found no significant difference in glutathione-S-epoxide transferase activity in hair follicles between smokers and non-smokers, suggesting this enzyme's levels may not indicate polycyclic aromatic hydrocarbon-related cancer risk.

This study isolated highly pure oleanolic and maslinic acids from olive milling residues, exploring their chemical reactions, including the formation of finasteride precursors.

This research describes the synthesis of 16β-chloro- and 16β-bromo-cyproterone acetate, detailing the chemical processes involved, but reports no clinical outcomes.

This article summarizes the properties, synthesis, and biomedical applications of molecules with N-oxide functionalities, emphasizing their growing role in healthcare due to their unique properties, such as water solubility and redox reactivity, crucial for drug targeting and cytotoxicity.

In this study, the synthesis of C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone revealed an unexpected formation of a C-4 substituted product using a 6-bromo derivative, contrary to prior reports.

This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.

This study found that antiandrogenic compounds in Curcuma aeruginosa, including germacrone, degrade rapidly at high temperatures but are more stable when solubilized in PEG-40.

This article provides a reference guide for various dermatological terms, treatments, and conditions, but reports no new clinical findings.

In this study, terbinafine reached high concentrations in stratum corneum and sebum after oral administration, with drug levels remaining above fungicidal concentrations for over three weeks.

This study reported that 4D-printed, aliphatic polycarbonate-based scaffolds supported adipose tissue engineering by allowing adipocyte infiltration and neovascularization in vivo, indicating potential for effective adipose tissue repair.

This study reported that certain newly synthesized steroidal derivatives showed stronger inhibitory activity against the 5α-reductase enzyme than finasteride in hamsters, suggesting their potential as enzyme inhibitors.

In this study, the researchers reported that their proposed methods accurately determined the studied drug with good recovery rates despite the presence of oxidative degradation products.

This case report documents warfarin-induced alopecia in a 39-year-old male in Southern India, adding to the limited case reports on this potential side effect.

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.

This review discusses the potential autoimmune pathogenesis and various contributing factors of alopecia areata, noting that current treatments remain palliative while emerging therapies offer new hope for extensive cases.

This article reviews the role of skin surface lipid in mediating environmental stressors and discusses potential therapeutic interventions, reporting no new experimental findings.

This study found that maternal PPARγ is essential for preventing the production of inflammatory lipids in mouse milk, which can otherwise cause inflammation, alopecia, and growth retardation in nursing pups.

This review discusses the properties and therapeutic potentials of beta-sitosterol, highlighting a need for more detailed studies on its mechanisms and long-term effects in humans; it reports no new results.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This study found that disrupting Stat3 in keratinocyte stem cells of mice reduced skin tumor formation by approximately 80%, suggesting Stat3's role in tumor initiation survival mechanisms.

This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.

This article reviews recent advances in the synthesis of oxasteroids and reports no new experimental results.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This case report describes a patient with an allergic sensitization to minoxidil, indicating that such patients should pursue alternative therapies to treat androgenetic alopecia.

This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.

This review explores the role of fatty acids and bioactive lipid mediators in skin health and suggests targeting this metabolic network to control inflammation and improve skin conditions, but it reports no new findings.

This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.