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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The virus was not found in the semen and urine of a man who tested positive for COVID-19.

Sebocytes play a key role in controlling androgen levels in human skin.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

COVID-19 can cause different skin symptoms that may help with early diagnosis and show how severe the disease is.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

A man with vitiligo and alopecia saw quick skin and hair improvement with ruxolitinib, but skin color gains were lost after stopping treatment.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Finasteride safely lowers DHT levels without affecting testosterone.

Too much androgen can cause hair loss; finasteride may help.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Liposomes and niosomes improve finasteride delivery for hair loss treatment.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

Testosterone treatment in trans men increases body and facial hair and may lead to hair loss over time, but severe skin issues are rare.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.