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390-420 / 1000+ resultsresearch Mdm2-p53 Signaling in Tissue Homeostasis and the DNA Damage Response: A Dissertation
This study found that Mdm2 is critical for limiting p53 activity to maintain normal stem cell function in mouse skin, with impacts on tissue homeostasis and aging.
research DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration
This study found that lncRNA2919 negatively impacts hair follicle regeneration by decreasing follicle depth and density in a rabbit model, suggesting a regulatory role in the hair follicle cycle through DNA methylation.
research Pharmacological Mobilization of Endogenous Stem Cells Significantly Promotes Skin Regeneration after Full-Thickness Excision: The Synergistic Activity of AMD3100 and Tacrolimus
This study demonstrated that combining AMD3100 with low-dose tacrolimus in a stem cell mobilization approach significantly reduced wound healing time and improved scar and hair follicle regeneration in full-thickness skin wounds.
research Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster.
This study found that TCDD significantly reduced EGF receptor binding in various animal models, linked to toxic symptoms like weight loss and developmental delays, with receptor phosphorylation persisting several days.
research Anaphylactic Shock Due to Intravenous Amiodarone; Delusional Parasitosis Associated with Donepezil; Connubial Androgenetic Alopecia; Ciprofloxacin-Induced Torsade de Pointes; Postvaccination Miller Fisher Syndrome; Life-Threatening Anaphylactoid Shock Caused by Recombinant Tissue Plasminogen Activator; Thiazide-Induced Hyponatremia
This article discusses the importance of raising awareness about specific adverse drug reactions, methods of prevention, and the significance of reporting them to the FDA's MedWatch program, but reports no new clinical results.
research Management of Infectious Emergencies for the Inpatient Dermatologist
research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies
This review discusses the relationship between ectodermal alterations and immunodeficiencies, particularly the roles of hyper-IgE syndrome, ectodermal dysplasia, and FOXN1 gene mutations, but it presents no new research findings.
research FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery
This study found that finite element analysis-guided design improved bubble microneedles' controlled tip separation and insertion strength, supporting effective transdermal and sublingual drug delivery.
research Ectodysplasin research—Where to next?
This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.
research Medulla loss of scalp hair in breast cancer patients determined by near-infrared microscopy
This study found that near-infrared microscopy can effectively detect complete medulla loss in scalp hair, which may serve as a potential biomarker for breast cancer diagnosis.
research 24 ARQ-234: a high affinity CD200-Fc fusion protein for the treatment of atopic dermatitis
This study found that engineered high-affinity soluble CD200R agonists, including ARQ-234, showed superior efficacy in reducing immune responses in various preclinical models of inflammatory conditions, suggesting potential as a therapeutic for atopic dermatitis and other related diseases.
research Alarm reaction of pilosebaceous apparatus
This study describes "alarm reaction" histologic changes in pilosebaceous structures, including regression of hair matrix and alterations in sebaceous glands, affecting follicular and sebaceous gland morphology.
research Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine
This study reported that an injectable hydrogel microparticle vaccine platform enhanced antibody responses and protection against influenza in mice, outperforming the traditional adjuvant aluminum hydroxide.
research 709 Nitric oxide-releasing topical therapeutic agent for atopic dermatitis
In this study, the novel isoprenylcysteine analog SIG-1451 was shown to inhibit pro-inflammatory cytokine release in various cell-based assays relevant to allergic dermatitis, acting on targets such as IL-4 and IL-6 with potential anti-inflammatory benefits.
research Immunolocalization of a Histidine-Rich Epidermal Differentiation Protein in the Chicken Supports the Hypothesis of an Evolutionary Developmental Link between the Embryonic Subperiderm and Feather Barbs and Barbules
In this study, researchers found that the EDMTFH protein is present in specific layers of the chicken embryo skin and feathers, suggesting its role in feather mechanics and development.
research Pathogenic CD8+ T cells target K71+ Henle’s layer by forming cytolytic immune synapses in Alopecia Areata
research Profibrotic Molecules Are Reduced in CRISPR-Edited Emery–Dreifuss Muscular Dystrophy Fibroblasts
This study found that fibroblasts from Emery-Dreifuss muscular dystrophy patients with certain genetic mutations overexpress markers of fibrosis, and gene correction techniques reduced fibrogenic molecule expression in cell models, suggesting potential therapeutic applications.
research The Free Communications of the Eighth Clinical Congress (Virtual) of the Gulf Chapter of the American Association of Clinical Endocrinologists; November 5–7, 2020
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research MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction
In this study, researchers developed EPO-derived peptides that enhanced hair growth by stimulating dermal papilla cells and increasing IGF-1 expression without triggering systemic erythropoietic effects in tested models, indicating a promising approach for treating hair loss.
research LB1256 TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants
TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
research Pseudallescheria boydii infection associated with IgG4-related disease
This report identifies a novel splice-site variant in the LAMB3 gene linked to junctional epidermolysis bullosa, emphasizing the need for gene sequencing in diagnosing the disease.
research A blistering child: sudden erythema with blisters in a sick girl
This study identified a novel splice-site variant of the LAMB3 gene that may cause junctional epidermolysis bullosa, suggesting gene sequencing is essential for accurate diagnosis.
research 887: METHYLENE BLUE AS RESCUE THERAPY IN REFRACTORY HYPOTENSION FOLLOWING MINOXIDIL OVERDOSE
In this case study, treatment with methylene blue successfully improved blood pressure in a patient with refractory vasodilatory shock due to massive minoxidil ingestion, highlighting its potential as an adjunctive therapy.
research EMOTIONAL INTELLIGENCE MEASUREMENT SELECTING
This article reviews existing instruments for measuring emotional intelligence, comparing time-established and popular questionnaires, but it provides no new research findings.
research Palmitoylethanolamide-Incorporated Elastic Nano-Liposomes for Enhanced Transdermal Delivery and Anti-Inflammation
This study found that using elastic nano-liposomes to deliver palmitoylethanolamide improved its transdermal delivery and enhanced its skincare effects, with minimal cytotoxicity and no allergic reactions observed.
research Dynamet wins titanium award
This study found that dihydrotestosterone induces hair loss in male C57BL/6 mice, and this effect can be partially reversed by the androgen receptor antagonist bicalutamide.
research Cationic Ionic Liquid-Liposome Nanoplatform for Transdermal asiRNA Delivery: A Unified Therapy for Androgen-Dependent Dermatoses
research Finasteride 98319‐26‐7
research A woman with iatrogenic androgenetic alopecia responding to finasteride
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