Effects of In Vivo-Administered 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Receptor Binding of Epidermal Growth Factor in the Hepatic Plasma Membrane of Rat, Guinea Pig, Mouse, and Hamster
December 1984
in “
Proceedings of the National Academy of Sciences
”
TLDR TCDD reduces EGF receptor activity and causes various developmental changes in animals.
The study investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on epidermal growth factor (EGF) receptor activity in the hepatic plasma membrane of various animals. TCDD significantly reduced EGF binding in rats at low doses, correlating with weight loss, and similar effects were observed in guinea pigs and mice, with varying sensitivity among species and strains. In mice, TCDD exposure led to early eye opening, incisor eruption, weight loss, and delayed hair growth, linked to EGF effects. TCDD also stimulated EGF receptor phosphorylation in rats. The study suggested that TCDD's EGF-like effects, such as liver fatty infiltration and cell proliferation, might be due to its impact on EGF receptors.
