96 citations
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September 2017 in “Analytica Chimica Acta” This review discusses the growing use of scalp hair for elemental analysis in various fields and highlights advancements in analysis techniques, including the future potential of laser ablation ICP-MS, but reports no new clinical results.
This study observed a decrease in iodine, lithium, and lead concentrations in hair samples from Venezuelan subjects over 20 years, with regional variations noted for selenium, uranium, and mercury.
January 2019 in “Trace Elements in Medicine (Moscow)” Hair analysis may help monitor health in children with Down syndrome and obesity.
1 citations
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August 1985 in “Proceedings annual meeting Electron Microscopy Society of America” This study discusses using SEM/EDX for elemental analysis of hair samples in forensic science but notes challenges in detecting certain trace elements from raw hair.
January 2011 in “Nuclear Techniques” This study found that lead accumulated in the hair shafts of individuals exposed to mining environments, while iron, copper, and zinc levels remained stable, highlighting the significance of SRXRF micro-analysis for environmental health research.
5 citations
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January 2012 in “Natural Science” This study analyzed the elemental content of three medicinal herbs used for general weakness and found they contain varying amounts of bioavailable minor and trace elements, with insignificant levels of toxic elements.
September 2025 in “Pakistan Journal of Science” This study observed that individuals with type 1 diabetes mellitus have notably lower levels of essential and trace elements like Calcium, Potassium, and Zinc in biological samples compared to non-diabetic controls.
2 citations
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January 2004 in “AIP conference proceedings” This study suggests that hair analysis detecting trace elements like copper and iron may help in screening for diseases such as hepatocellular carcinoma and osteoporosis, due to altered element concentrations in patients.
September 2001 in “PubMed” This study developed a non-destructive X-ray fluorescence technique to quantitatively analyze elemental content in human hair and constructed a database of element concentrations in healthy Swedish, Caucasian individuals.
109 citations
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January 1980 in “Science of the total environment” This paper reviews chemical analysis methods for trace elements in human hair and supports a no-wash policy due to challenges in distinguishing between endogenous and exogenous element sources.
January 2024 in “Biological trace element research” In this study, isotretinoin treatment for acne vulgaris was associated with changes in plasma phosphorus, potassium, magnesium, and zinc levels, potentially affecting kidney function and contributing to side effects like fatigue and dry skin.
23 citations
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February 2017 in “Journal of dermatology” This meta-analysis suggests that patients with alopecia areata have lower serum levels of zinc and selenium compared to healthy controls, which may be important risk factors for the condition.
5 citations
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January 1997 in “Journal of Occupational Health” The method effectively maps lead and zinc in hair, aiding understanding of heavy metal exposure risks.
This study found that telogen effluvium is strongly linked to lower serum levels of ferritin and vitamin D, especially in predominantly female patients.
5 citations
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July 2014 in “Journal of X-Ray Science and Technology” This study suggests that hair analysis could serve as a diagnostic tool for detecting calcium channel activity, which influences hair calcium levels and may indicate calcium deficiency or related disease states.
February 2026 in “Macromolecular Bioscience” In this study, keratin‐based hydrogels incorporating calcium ions were developed to effectively deliver atorvastatin, showing potential for localized anti‐fibrotic therapy through controlled drug release and maintaining drug bioactivity in vitro, supported by thorough physicochemical and mechanical characterization.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that diabetic individuals had significantly lower hair levels of chromium, manganese, and copper, but higher iron levels, compared to non-diabetic controls.
5 citations
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December 2024 in “Journal of Cosmetic Dermatology” Vitamin D and zinc may help treat alopecia areata.
March 2026 in “Skin Appendage Disorders” This study reviewed multiple research articles and found that patients with telogen effluvium, primarily women, had significantly lower levels of serum ferritin and vitamin D compared to healthy controls, suggesting a role for trace element imbalances in hair loss.
This systematic review and meta-analysis found that patients with telogen effluvium, primarily females, exhibited significantly lower serum levels of ferritin and vitamin D compared to healthy controls, suggesting trace element imbalances play a crucial role in this type of hair loss.
January 2012 in “TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES AEROSPACE TECHNOLOGY JAPAN” This paper outlines the research plan and current progress of a study analyzing mineral metabolism changes in astronauts by examining hair shafts after long-term space flight, with no new results yet.
17 citations
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February 2022 in “Microscopy Research and Technique” This study reports that different animal species exhibit distinct hair scale patterns and elemental compositions, which can aid forensic investigations in identifying animal hair.
1 citations
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June 2025 in “Environmental Research” In this study, researchers reported that adult females approaching menopause in Canada generally had similar or lower blood concentrations of toxic, essential, and trace elements compared to their peers, but most participants showed zinc levels below the proposed adequacy threshold.
2 citations
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July 2025 in “Analytical Chemistry” This study reported the development of a workflow that combines SIMS and X-ray elemental mapping techniques for multimodal imaging at the single cell level, successfully applied to visualize elements, metals, and lipids in porcine skin without loss or delocalization.
January 1994 in “中医杂志:英文版” This study found that aplastic anemia patients with deficiencies in yin, yang, or both had reduced levels of various trace elements in their hair compared to healthy controls.
7 citations
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July 2008 in “Experimental Dermatology” This study identified molecular elements controlling the expression and stabilization of THH protein in hair follicle cells, revealing key mechanisms that support hair shaft development in mice.
3 citations
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April 2023 in “Journal of Veterinary Internal Medicine” This study found that dogs with idiopathic epilepsy had altered hair concentrations of several trace elements, which may suggest a role in the disease's pathophysiology and indicate effects from antiseizure medications.
June 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that women with diffuse alopecia exhibited deficiencies in several trace elements, including sulfur, iron, and potassium, while men showed deficiencies in calcium, sulfur, and zinc.
10 citations
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June 2022 in “Development” This study suggests that distinct chromatin topologies allow different lineage-specific enhancers to regulate Hoxd genes in mouse vibrissae and chicken feather primordia, while conserved regulatory elements maintain transcriptional robustness in the embryonic trunk across species.
2 citations
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August 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that distinct subsets of Hoxd genes in murine vibrissae and chicken feather primordia are regulated by different lineage-specific enhancers, indicating evolutionary changes in chromatin topology contribute to transcriptional robustness.