research Multiple Sclerosis Disease-Modifying Therapies: Adverse Effect Surveillance and Management
The document concludes that managing side effects of MS therapies is crucial for treatment success and patient adherence.
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research A Microscopy-Based Small Molecule Screen in Primary Neurons Reveals Neuroprotective Properties of the FDA-Approved Anti-Viral Drug Elvitegravir
The anti-viral drug Elvitegravir may protect brain cells from damage related to neurodegenerative diseases.
research The Neurobiology of Sexual Function
Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.
research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients
Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.
research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride
Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
research Baiting Proteins with C60
C60 fullerenes can alter protein function and may help develop new disease inhibitors.
research Physiological Functions of PP2A: Lessons from Genetically Modified Mice
Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.
research The Action of Diazoxide and Minoxidil Sulphate on Rat Blood Vessels: A Comparison with Cromakalim
Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
research Weekly Docetaxel in Minimally Pretreated Cancer Patients: A Dose-Escalation Study Focused on Feasibility and Cumulative Toxicity of Long-Term Administration
Giving docetaxel weekly at 40 mg/m² is manageable and has low toxicity for cancer patients.
research Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride
Progesterone boosts alcohol's effect on brain, finasteride counters it.
research Neonatal Finasteride Induces Anxiogenic-Like Profile and Deteriorates Passive Avoidance in Adulthood After Intrahippocampal Neurosteroid Administration
Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.
research Clinical Characterization of Men with Long QT Syndrome and Torsades de Pointes Associated with Hypogonadism: A Review and Pharmacovigilance Study
Low testosterone in men is a risk factor for a specific heart rhythm issue, and testosterone treatment may help prevent it.
research Teriflunomide: A Novel Oral Treatment for Relapsing Multiple Sclerosis
Teriflunomide is an effective and safe first-line oral treatment for relapsing multiple sclerosis.
research Current Concepts in Aesthetic Endocrinology
Hormones affect skin aging and fat distribution, and treatments can help, but only minoxidil is proven for female hair loss.
research Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath
Activating TRPV3 channels stops hair growth by killing hair follicle cells.
research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury
Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.
research The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia
A new gel form of minoxidil is equally effective for hair growth and safer for the heart and other organs than the traditional solution.
research Keratin
Understanding how keratin structures in hair are arranged and interact is key for creating methods to extract and purify them.
research How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap
Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.
research Follicle-Innervating Aδ-Low Threshold Mechanoreceptors Organize Through a Population-Dependent Mechanism
Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.
research Autoimmunity in Satoyoshi Disease: A Systematic Review
Satoyoshi syndrome is likely an autoimmune disease that mainly affects young women and improves with immune-related treatments.
research Possible Contributory and Protective Factors in Medication Associated Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System
Some drugs may increase the risk of obstructive sleep apnea, while others like certain biologics might decrease it.
research Nociceptive and Non-Nociceptive Roles of TRPV3 and Its Druggability
TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
research Reporting on Adverse Clinical Events
Monitoring for adverse effects in clinical treatments is crucial.
research Neurosteroids on the Epilepsy Chessboard: Keeping Seizures in Check
Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.
research Impact of Low Dose Finasteride for the Treatment of Androgenic Alopecia on Serum Prostate Specific Antigen Levels in Men Participated in Population-Based Screening for Prostate Cancer
Low dose finasteride causes only minor changes in PSA levels in men over 50 with BPH.
research Neuronal Mimicry as a Resistance Phenotype in Cancer Cells
Low dose finasteride causes only small changes in PSA levels in older men with BPH.
research TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons
TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.
research Root Hair Growth in Arabidopsis Thaliana Is Directed by Calcium and an Endogenous Polarity
Calcium affects where root hairs grow, but other unknown factors determine their growth direction.
research Tactile Innervation Densities Across the Whole Body
Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.