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This study found that cathepsin L deficiency in mice led to significant abnormalities in hair follicle development and cycling, including disrupted hair shaft outgrowth and premature hair growth phase entry.

This research abstract outlines the innovative approach of the Frontiers journal series, which aims to transform academic publishing by providing open access, interdisciplinary journals that employ a rigorous peer-review process to serve both scholarly communities and the public.

In this study, estetrol (E4) treatment was associated with increased hair growth in ex vivo human hair follicles, suggesting its potential as a treatment for hair loss disorders.

This study observed that using ex vivo gene therapy to modify skin cells in a pre-graft model improved dermal-epidermal junction adhesion strength and maintained collagen production over time, suggesting a potential treatment approach for recessive dystrophic epidermolysis bullosa skin wounds.

A bull with a gene mutation was asymptomatic, synthetic retinoids cause hair loss, and new therapeutic targets were identified for skin diseases.

In this study, Er:YAG laser therapy initially improved the appearance of eruptive vellus hair cysts but was ultimately ineffective due to early recurrence and concerns about atrophy or scarring.

This report describes a 27-year-old patient with Ehler-Danlos syndrome who also presented with hypophosphatasia and mastocytosis, and suggests enzyme replacement therapy might alleviate symptoms in such overlapping genetic conditions.

In this study, cystaselenonine treatment in mice resulted in hair loss limited to older growing hairs and delayed regrowth, while also causing temporary weight loss.

In this study, researchers re-evaluated biopsies from elderly patients with erosive pustular dermatosis of the scalp and identified plasma cell and lymphocyte infiltrates as key histological indicators for diagnosis, observing that high-potency topical steroids effectively healed the lesions.

This study compared hydrolysed wheat protein, L-arginine, and hydrolysed collagen for their effectiveness in enhancing the tensile strength of heavily bleached hair.

This study observed that erosive pustular dermatosis of the scalp in elderly patients was effectively treated with high-potency topical steroids, with plasma and lymphocyte dermal infiltrates helping to confirm diagnosis.

Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.

This article highlights that erosive pustular dermatosis of the scalp is often under-diagnosed in the United States, potentially leading to unnecessary surgery.

This article discusses challenges in hair restoration surgery and reports no new clinical results.

In this study, certain cysteine residues in Romney sheep wool fibers were labeled more often during stretching tests, particularly under wet conditions, suggesting variability in their disulfide bond contributions to fiber mechanics depending on hydration.

This study used histopathological and ultrastructural analyses to differentiate between junctional epidermolysis bullosa and dermatomyositis-like disease in two juvenile dogs with skin disorders.

This study observed defects in hair cuticle cross-linking in some, but not all, mouse mutants with sparse or structurally unsound hair.

In this study, PINCH-1 gene loss in mouse epidermis led to detachment from the basement membrane, thickened skin, and hair loss, with findings suggesting PINCH-1 plays a role in keratinocyte adhesion through both ILK and EPLIN pathways.

This review discusses potential EMT-targeting drugs for treating lichen planopilaris and emphasizes the need for clinical trials, as current evidence is limited to individual cases or case series.

This study observed that areola formation in mice requires exposure to pregnancy hormones and mechanical strain, beyond individual stimuli like hormonal milieu or strain alone.

This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.

This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

Telogen effluvium causes sudden hair loss, often due to stress or changes, and is treated by addressing the cause and offering support.

This study found that MAPK/ERK signaling plays a key role in driving tissue regeneration in spiny mice and suggests potential for reversing fibrosis to promote regeneration in mammals.

This study describes a method to create keratin hydrogels with adjustable erosion rates by mixing different ratios of keratose and kerateine, enabling controlled release of therapeutic agents like insulin-like growth factor 1.

This case study reports that pancreatic enzyme replacement and fatty acid supplementation improved symptoms of fat malabsorption and essential fatty acid deficiency in a patient with EDS-4.

This article reviews the causes and treatments of fine rhytids, highlighting the potential effectiveness of laser rejuvenation therapies but presents no new clinical results.

This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.

This study found that papain/bisulfite disintegrates human hair cuticles by dissolving the endocuticle, potentially accelerated by ethanol's removal of cell membrane material.