2 citations
,
February 2023 in “Transgenic Research” In this study, the presence of the HPV11-E2 protein in transgenic mice was found to increase and vary the expression of a reporter gene in hair follicle bulge regions.
1 citations
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May 2023 in “PubMed” The researchers in this study identified a new subpopulation of dermal fibroblasts in neonatal murine dermis marked by EGFR, which they report contributes to hair follicle regeneration through the promotion of IGF1, potentially aiding in wound-induced hair follicle neogenesis.
March 2024 in “Current materials science” This study explores the various properties of the flavonoid fisetin, highlighting its potential therapeutic applications due to its ability to modulate numerous biological pathways, suggesting benefits in conditions like inflammation, cancer, and neurodegenerative diseases.
6 citations
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August 2024 in “Experimental Dermatology” This study found that irisin, a myokine, increases hair growth by activating the Wnt/β-catenin pathway, enhancing cell proliferation and hair shaft elongation in both human cell and mouse models.
1 citations
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July 2024 in “Journal of Investigative Dermatology” MPZL3 protein affects hair growth cycles and could help manage hair loss.
10 citations
,
April 2020 in “PloS one” This study found that mitochondrial dysfunction due to Crif1 deficiency in hair follicle stem cells significantly slows the hair growth cycle in adult mice but does not impact the maintenance of HFSC populations.
10 citations
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May 2012 in “PloS one” This study found that non-pigmented hair follicles have significantly lower expression of nucleotide excision repair genes, which may be associated with reduced melanin production capacity in these follicles.
September 2022 in “European Journal of Dermatology” This study identified a novel pathogenic splice-site variant of the LAMB3 gene in patients with junctional epidermolysis bullosa, highlighting the importance of gene sequencing for diagnosis.
37 citations
,
December 2020 in “PLANT PHYSIOLOGY” In this study, the researchers identified a temperature-sensitive mutant in Arabidopsis thaliana, showing disrupted root hair formation and altered responses to plant hormone treatments at elevated temperatures.
9 citations
,
October 1989 in “Australian Journal of Agricultural Research” This study found that infused mouse epidermal growth factor induced wool follicle involution through a quasi-physiological process similar to catagen and a separate pathological action, resulting in fleece 'break' or shedding.
This study reports that a novel series of compounds can potently and selectively inhibit glycogen synthase kinase-3, which activates glycogen synthase in insulin receptor-expressing cells and primary rat hepatocytes.
September 2023 in “Plant journal” This study showed that the zinc finger protein GIS3 is important for root hair growth in Arabidopsis by regulating RHD2 and RHD4 genes, with application of ethylene and cytokinin helping restore root hair presence in mutated variants.
32 citations
,
January 2010 in “Journal of Dermatological Science” In this study, Waved-5 mice with reduced EGFR signaling showed nearly normal skin and hair follicle function but experienced a transient reduction in subcutaneous fat.
April 2023 in “Journal of Investigative Dermatology” This study suggests that MPZL3, a mitochondrially localized protein, may play an integral role in regulating hair follicle cycles, with potential therapeutic implications for hair growth disorders if findings translate to humans.
41 citations
,
February 2005 in “Experimental Cell Research” This study suggests that the MAEG protein may facilitate epithelial–mesenchymal interactions during hair follicle development by binding to RGD-binding integrins like α8β1.
7 citations
,
March 2020 in “Journal of the American Academy of Dermatology” This study observed that trichoscopic changes associated with EGFRI treatment include pili torti and asymmetric hyperpigmented fusiform widening, along with dermoscopic skin manifestations such as scale and branching vessels.
24 citations
,
January 2018 in “Development” This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.
January 2023 in “Indian dermatology online journal” This case report describes a novel NECTIN4 gene mutation linked to ED-syndactyly syndrome 1 in a young girl, contributing to the understanding of this rare ectodermal dysplasia.
9 citations
,
June 2021 in “Nutrients” In this study, fisetin applied to the dorsal skin of mice activated hair follicle stem cells through exosome secretion from keratinocytes, promoting hair growth.
March 2026 in “European Journal of Medical and Health Research” In this case-control study, researchers observed that women with female pattern hair loss exhibited significantly lower serum IGF-1 levels than controls, while IGFBP-3 levels showed no significant difference, suggesting a potential role for IGF-1 in the condition.
98 citations
,
December 2015 in “The Journal of Cell Biology” In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.
19 citations
,
January 2012 in “Dermatology” This study describes three cases of acneiform eruptions from EGFR inhibitors that improved with topical recombinant human EGF, suggesting its potential as a treatment option for this side effect.
3 citations
,
September 2022 in “European Journal of Dermatology” This report identifies a novel splice-site variant in the LAMB3 gene linked to junctional epidermolysis bullosa, emphasizing the need for gene sequencing in diagnosing the disease.
5 citations
,
January 2015 in “Case reports in medicine” In this case report, a novel missense mutation c.1360G>C (p.Ala454Pro) in the MBTPS2 gene was identified in a boy with typical IFAP syndrome and severe atopic features, although no phenotype/genotype correlation was established.
2 citations
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January 2001 in “Biomedical Research” This study found that peptidylarginine deiminase type III and trichohyalin are coincidentally expressed in the infant rat hair follicle, but trichohyalin deimination occurs after their expression during development.
47 citations
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June 1994 in “Experimental Cell Research” mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
April 2018 in “Journal of Investigative Dermatology” In this study, the authors identified a role for hair follicles in regulating the formation and sympathetic innervation of arrector pili muscles, influencing hair follicle stem cell activity and potentially explaining hair loss associated with beta-blockers and androgenic alopecia.
1 citations
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January 2022 in “Annals of Dermatology” In this case report, researchers identified a novel homozygous missense mutation in the MBTPS2 gene associated with the mild form of IFAP syndrome in a 7-year-old boy.
1 citations
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October 2010 in “2010 3rd International Conference on Biomedical Engineering and Informatics” This study successfully cloned and characterized the LEF-1 gene from Inner Mongolia Cashmere Goats, potentially aiding efforts to enhance cashmere production through genetic modification.
24 citations
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May 2019 in “PLOS genetics” This study reports that compound heterozygous loss-of-function mutations in the HEPHL1 gene in a child were associated with abnormal hair and cognitive issues, linking altered ferroxidase activity to hair disorders.