Potential Biomolecule Fisetin: Molecular and Pharmacological Perspectives
March 2024
in “
Current materials science
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TLDR Fisetin, found in fruits and vegetables, may help treat various health conditions like inflammation, diabetes, heart issues, cancer, and hair loss.
Fisetin, a naturally occurring dietary flavonoid found in various fruits and vegetables, has garnered significant research interest due to its safety, affordability, and practicality for oral administration. Its bioavailability and biological activity are influenced by its structural configuration and hydroxyl group composition. Fisetin modulates numerous molecular pathways, such as PI-3 kinase/AKT/p38 and NF-κB/I-κBα, contributing to its wide range of pharmacological activities. These include antihyperalgesic, antileishmanial, anti-inflammatory, antidiabetic, antihypertensive, cardioprotective, anti-cancer, and hair growth-promoting effects. The study highlights fisetin's potential therapeutic applications across various health conditions, emphasizing its pleiotropic properties.
