54 citations
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March 2012 in “International Journal of Andrology” This study found that prenatal exposure to certain pesticides may lead to earlier breast development in girls, potentially associated with higher androgen levels.
29 citations
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February 2019 in “Environment international” This study found that higher prenatal and early childhood lead exposure may be associated with delayed pubertal development in girls, but not in boys, in Mexico City.
April 2025 in “International Journal For Multidisciplinary Research” This case report details the investigation and management of a 3-year-old girl with precocious pseudopuberty due to a Sertoli-Leydig cell tumor, highlighting the importance of early recognition and accurate diagnosis for effective treatment and prognosis.
6 citations
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May 2021 in “JAMA network open” This study reported that higher weight-for-age z scores and rapid weight gain during infancy, especially from birth to 3 months, were linked to an increased likelihood of puberty onset in girls.
4 citations
,
December 2021 in “Journal of Clinical Nursing” This study observed that women with early-stage breast cancer often felt inadequately prepared for the discomfort and time commitments of scalp cooling during chemotherapy, leading to the development of patient-co-produced informational resources to better prepare them.
1 citations
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March 2025 in “Archivos Argentinos de Pediatria” This study found that exposure to phytoestrogens, bisphenol A, parabens, and phthalates was associated with developing idiopathic premature thelarche in girls.
2 citations
,
January 2000 in “Pediatrics in review” This article discusses diagnostic evaluations and management strategies for isosexual precocious puberty, emphasizing the importance of accurate identification and appropriate treatment, but it provides no new clinical findings.
August 2020 in “Nigerian journal of paediatrics” This case report describes a 24-month-old girl from Nigeria with idiopathic precocious puberty, emphasizing the financial barriers to necessary treatment in developing countries.
11 citations
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August 2017 in “Supportive care in cancer” This study highlights the significant impact of eyebrow and eyelash loss during chemotherapy on women's quality of life, noting both emotional and physical challenges.
20 citations
,
May 1998 in “PEDIATRICS” This correspondence highlights a study on early pubertal development in young girls, noting that early pubic hair and breast development in African-American girls is likely due to increased androgen production, not estrogen or exogenous causes.
2 citations
,
July 2008 in “Paediatrics & child health” This case report describes a 10-year-old girl with advanced puberty signs and resistant acne, highlighting potential early-onset puberty with associated growth patterns.
8 citations
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September 2014 in “Journal of X-Ray Science and Technology” This study found that hair analysis may be useful in early breast cancer detection by identifying distinct calcium and strontium concentration patterns before and during cancer development.
October 2022 in “Medical Clinical Update Journal” This case report describes a 7.5-year-old girl with precocious puberty displaying significant secondary sexual development and advanced bone age, treated monthly with Leuprolide.
September 2002 in “Fertility and sterility” This study found that adolescent girls with PCOS experienced earlier thelarche and menarche compared to controls, and the authors suggest these patterns may relate to hyperandrogenism and increased body mass index.
February 2025 in “Medicine” This study identified multiple environmental, dietary, and familial risk factors associated with precocious puberty in girls, such as exposure to cosmetics, frequent consumption of snacks, and mother's early pubertal development.
21 citations
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September 2004 in “Fertility and Sterility” Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.
November 2024 in “Revista de Investigación y Educación en Ciencias de la Salud (RIECS)” In this case study, a 7-year-old girl was diagnosed with Isolated Premature Pubarche after presenting with pubic hair growth and normal hormonal and bone age assessments.
September 2005 in “電子情報通信学会ソサイエティ大会講演論文集” This review discusses various cancer prevention strategies, summarizing established successes like tamoxifen for breast cancer and mixed outcomes of preventive trials like finasteride for prostate cancer, and reports no new results.
15 citations
,
May 2010 in “Pediatrics in Review” This article reviews the normal and delayed maturation of the HPG axis and pubertal development in boys and girls, emphasizing clinical aspects of diagnosing and managing delayed puberty, but it reports no new clinical findings.
55 citations
,
April 2010 in “Cancer and Metastasis Reviews” This article discusses the complex role of TGFβ in cancer progression, highlighting its dual function as both a tumor suppressor in early stages and a promoter in later stages, without reporting new results.
In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.
9 citations
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August 1986 in “Archives of Pediatrics and Adolescent Medicine” In this study, among 58 girls diagnosed with isosexual precocious puberty, 5.2% had family histories of sexual precocity, indicating familial patterns may be more common than previously thought.
April 2019 in “Journal of the Endocrine Society” This case study highlights the late diagnosis of complete androgen insensitivity syndrome in a 31-year-old woman, emphasizing the psychological impact and need for individualized treatment guidelines.
56 citations
,
August 2011 in “Best Practice & Research Clinical Gastroenterology” Cancer prevention has progressed with successful drugs and vaccines, but challenges remain in understanding genetic changes and improving strategies.
23 citations
,
December 2013 in “Molecules” This study found that the evodiamine derivative 2-16 exhibited the highest antitumor activity and a broad spectrum of activity against various human cancer cell lines, with improved solubility.
5 citations
,
March 2017 in “Immunology and Cell Biology” This review discusses recent advances in biomedical imaging for cancer research, particularly highlighting improved imaging tools for studying solid tissue malignancies, and reports no new clinical results.
January 2026 in “International Journal of Women s Health” This study found that a nomogram prediction model based on clinical characteristics, bone metabolism, and ovarian function can effectively predict the treatment response to long-acting GnRHa in girls with idiopathic central precocious puberty.
7 citations
,
February 2004 in “Clinical and Experimental Ophthalmology” This case report details a 65-year-old woman who developed malignant melanoma in her right eye socket following previous eye trauma, treated by orbital exenteration.
5 citations
,
October 2014 in “Methods” This article describes how PESCADOR software assists in creating detailed biological pathway charts from PubMed abstracts, focusing on hair and breast development case studies without providing new clinical results.
3 citations
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December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.