Endocrine Disruptors as Risk Factors for Idiopathic Premature Thelarche in Girls: A Case-Control Study

March 2025 in “ Archivos Argentinos de Pediatria ”

Florencia I Palmieri, Mirta Gryngarten, Andrea Arcari, Verónica Umido, Analía V. Freire

endocrine disruptors estrogenic action idiopathic premature thelarche phytoestrogens BPA bisphenol A phthalates parabens estrogen-like chemicals early breast development plant estrogens plastic chemicals plasticizers preservatives

Studysummary This study found that exposure to phytoestrogens, bisphenol A, parabens, and phthalates was associated with developing idiopathic premature thelarche in girls. Our plain-language summary of this paper — not a Tressless recommendation.

This case-control study investigated the association between exposure to endocrine disruptors (EDs) with estrogenic action and idiopathic premature thelarche (IPT) in girls aged 3 to 8. The study involved 50 cases and 48 controls, revealing significant associations between IPT and exposure to phytoestrogens in food (OR: 14.6), BPA containers exposed to temperature changes (OR: 2.6), phthalates (OR: 2.9), and parabens (OR: 2.7). The degree of exposure to these EDs also correlated with IPT development, suggesting that these substances may be risk factors for IPT.

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