Factors Affecting Bone Maturation in Chinese Girls Aged 4-8 Years With Isolated Premature Thelarche
July 2020
in “
Research Square (Research Square)
”
Studysummary This study found that girls with isolated premature thelarche, confirmed by GnRH stimulation test, aged 4-8 years, may have significantly advanced bone age, with obesity and serum IGF-1 and DHEAS levels being key risk factors.
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The study analyzed bone age (BA) and potential influencing factors in 423 Chinese girls aged 4-8 years with isolated premature thelarche (IPT). It found that 48.7% of the subjects had advanced BA, which was significantly associated with higher body mass index (BMI) standard deviation score (SDS), insulin-like growth factor-1 (IGF-1) SDS, and dehydroepiandrosterone sulfate (DHEAS) SDS. Obesity was strongly linked to advanced BA, and IGF-1 SDS, BMI SDS, and DHEAS SDS were identified as independent risk factors for BA advancement. These factors accounted for 19.3% of the variance in BA. The study concluded that obesity and specific hormone levels were significant risk factors for advanced BA in IPT girls, independent of BMI.
