Factors Affecting Bone Maturation in Chinese Girls Aged 4-8 Years With Isolated Premature Thelarche

    July 2020 in “ Research Square (Research Square) ”
    Huiping Su, Zhe Su, Lili Pan, Li Wang, Zhongwei Xu, Gang Peng, Xianglei Li
    TLDR Obesity and certain hormone levels can lead to advanced bone age in young girls with early breast development.
    The study analyzed bone age (BA) and potential influencing factors in 423 Chinese girls aged 4-8 years with isolated premature thelarche (IPT). It found that 48.7% of the subjects had advanced BA, which was significantly associated with higher body mass index (BMI) standard deviation score (SDS), insulin-like growth factor-1 (IGF-1) SDS, and dehydroepiandrosterone sulfate (DHEAS) SDS. Obesity was strongly linked to advanced BA, and IGF-1 SDS, BMI SDS, and DHEAS SDS were identified as independent risk factors for BA advancement. These factors accounted for 19.3% of the variance in BA. The study concluded that obesity and specific hormone levels were significant risk factors for advanced BA in IPT girls, independent of BMI.
    Discuss this study in the Community →