Factors Affecting Bone Maturation in Chinese Girls Aged 4-8 Years With Isolated Premature Thelarche

    July 2020 in “ Research Square (Research Square) ”
    Huiping Su, Zhe Su, Lili Pan, Li Wang, Zhongwei Xu, Gang Peng, Xianglei Li
    TLDR Higher BMI, IGF-1, and DHEAS levels are linked to advanced bone age in young Chinese girls with early breast development.
    The study analyzed bone age (BA) and potential influencing factors in 423 Chinese girls aged 4-8 years with isolated premature thelarche (IPT), confirmed by a GnRH stimulation test. It found that 48.7% of the subjects had advanced BA, which was significantly associated with higher body mass index (BMI) standard deviation score (SDS), serum insulin-like growth factor-1 (IGF-1) SDS, and dehydroepiandrosterone sulfate (DHEAS) SDS. Obesity was particularly linked to advanced BA, with the obesity group showing a higher proportion of advanced BA compared to normal weight and overweight groups. Serum IGF-1 SDS and DHEAS SDS were identified as independent risk factors for BA advancement, regardless of BMI.
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