Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that hamster sebaceous glands have high affinity binding sites for dihydrotestosterone, with competition from other steroids indicating specific binding characteristics.

This letter to the editor references a study on using dihydrotestosterone gel before hypospadias surgery but itself contains no new findings.

Lack of vitamin D receptor increases skin tumor risk by boosting hedgehog signaling.

In this report, a 54-year-old woman with familial dyskeratotic comedones showed slight improvement in skin lesions after topical retinoids and urea cream. This source also describes the first dermoscopic findings for this condition and reviews 21 previous cases.

This review discusses the free hormone hypothesis for measuring "free" testosterone and critiques its theoretical basis and clinical application, noting it lacks critical empirical testing and has inconsistent utility in assessing androgen status.

This study found that the diphosphonate ethan-1-hydroxy-1,1-diphosphonat was the most effective compound in preventing calcifications in rats induced by DHT, compared to other phosphatase inhibitors and polyphosphates tested.

This study reports that despite normal cystine incorporation into hair follicles, trichothiodystrophy patients have decreased cystine levels in hair shafts, contradicting the hypothesis of defective transport in hair follicles.

This study observed that individuals with Down syndrome exhibit early immune dysregulation, including multi-organ autoimmunity and hypercytokinemia, and found that the JAK inhibitor tofacitinib showed a good safety profile and reduced skin pathology in a Phase II trial.

In this case study, a 19-year-old woman with Henoch-Schönlein purpura, potentially triggered by hepatitis B vaccination, experienced improved symptoms after correcting low vitamin D levels and undergoing tonsillectomy, demonstrating these interventions may benefit similar patients.

This study found that disulfide bonds in keratin increase its strength and toughness, with some loss of α-helical structure under load, highlighting their role in trichocyte α-keratin's mechanical properties.

This study found no evidence that HDGF expression transforms melanocytes into tumors in a mouse model, although it may play a role in cell differentiation and tumor progression.

This study found that Twist1 and Tcf4 synergistically regulate the hair follicle induction ability of dermal papilla cells by forming a complex with β-catenin, enhancing their biological properties.

This study suggests that DHT may have a less potent effect on the prostate compared to testosterone while maintaining safety and similar effects on erythropoiesis and lipids.

This study revealed distinct cellular and transcriptomic differences among various subtypes of cutaneous T-cell lymphoma, particularly highlighting characteristics unique to folliculotropic mycosis fungoides.

This report describes two cases of urticarial id reaction linked to tinea capitis profunda, highlighting a potential new etiology for this rare condition.

This study demonstrated that both HR isoforms are expressed in keratinocytes, but HRDelta1072-1126 lacks corepressor activity and may act as a coactivator by inhibiting HDAC recruitment to the VDR transcriptional complex.

This study found that hair regrowth occurred in 72.2% of alopecia areata patients treated with diphencyprone, with disease extent at baseline and duration affecting outcomes.

This review discusses the regulation of the MiT-TFE family transcription factors, particularly TFEB, through phosphorylation-mediated subcellular localization and reports no new clinical results.

In a mouse model of peripheral vascular disease, this study found that recombinant thymosin β4 treatment increased expression levels of certain proteins, promoting angiogenesis.

This study found that in a mouse model with hereditary 1,25-dihydroxyvitamin D resistant rickets, a mutant vitamin D receptor lacking hormone-binding ability could restore normal hair cycling and affect parathyroid hormone regulation.

This study identified three EDAR gene variants potentially linked to hypohidrotic ectodermal dysplasia in three Pakistani families, which could aid in genetic counseling for similar cases.

This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

This study found that triiodothyronine and epidermal growth factor differentially affected craniofacial development in neonatal rats, with various impacts on hair growth direction, incisor eruption, and ear and eyelid development.

This article reports a case of trichothiodystrophy in a 7-year-old girl with sulfur deficiency in her hair, characterized by sparse, slow-growing hair and distinctive tiger tail banding under microscopy.

In this study, combining deferasirox with sorafenib significantly reduced liver fibrosis and preneoplastic lesions in rats while also lessening adverse effects compared to sorafenib alone.

This study found that Sonic Hedgehog secreted by hair follicle transit-amplifying cells is essential for dermal adipogenesis and hair follicle growth by acting on adipocyte precursors.

This study found that dexamethasone effectively suppressed DHEAS levels in women with elevated levels using much lower doses than previously thought, without significant adverse effects.

This study observed that gamma-ray induced apoptosis in ICR mouse hair follicles could be reduced by pretreatments with diethyldithiocarbamate or green tea, suggesting these agents as potential radioprotectors.

This study found that in mouse models, the novel NF-κB inhibitor DHMEQ improved symptoms of atopic dermatitis as effectively as tacrolimus or betamethasone.