Familial Dyskeratotic Comedones: A Case Report and Literature Review

July 2023 in “ Clinical Cosmetic and Investigational Dermatology ”

Kasama Tejapira, Poonkiat Suchonwanit

familial dyskeratotic comedones autosomal dominant comedone-like hyperkeratotic papules topical retinoids urea cream dermoscopic findings retinoids urea

Studysummary In this report, a 54-year-old woman with familial dyskeratotic comedones showed slight improvement in skin lesions after topical retinoids and urea cream. This source also describes the first dermoscopic findings for this condition and reviews 21 previous cases.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This case report and literature review focus on familial dyskeratotic comedones (FDC), a rare autosomal dominant skin condition. It highlights a 54-year-old Thai woman with FDC since age 12, emphasizing the condition's benign and asymptomatic nature, which often leads to underdiagnosis. The study reviews 21 cases from 11 families, stressing the importance of recognizing FDC's clinical and histological features for accurate diagnosis. Despite its rarity, FDC is resistant to treatment, with limited therapeutic options. The report also introduces new dermoscopic features to aid in differentiating FDC from similar conditions.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Alopecia Areata: An Autoimmune Disease of Multiple Players

31 citations , July 2021 in “ImmunoTargets and therapy”

This review compiles current evidence on the molecular mechanisms, etiologies, and targeted immunotherapies for alopecia areata and reports no new experimental results, emphasizing the need for further research to manage the disease.

research Topical Finasteride for the Treatment of Male Androgenetic Alopecia and Female Pattern Hair Loss: A Review of the Current Literature

13 citations , June 2020 in “Journal of Dermatological Treatment”

This review discusses the pharmacology and safety of topical finasteride for treating androgenetic alopecia and female pattern hair loss, noting positive results but reporting no new clinical findings.

research Alopecia in Association with Malignancy: A Review

26 citations , August 2018 in “American Journal of Clinical Dermatology”

This review discusses the clinical characteristics of alopecia in cancer patients, highlighting its potential role as an associated finding or diagnostic clue, but reports no new clinical results.