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research Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

April 2022

Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.

Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San

research Anti-Inflammatory Effects in LPS-Treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-San

December 2021 in “Daehanhanuihakoeji”

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

research Trends in 5-Alpha Reductase Inhibitor Use Before and After the Food and Drug Administration Safety Warning

April 2019 in “The Journal of urology/The journal of urology”

Prescriptions for 5-alpha reductase inhibitors dropped significantly after the FDA's safety warning, especially for men with benign prostatic hyperplasia.

research Development and Validation of UV Spectrophotometric Method for the Estimation of Finasteride Drug

December 2019 in “International journal of pharmaceutical quality assurance”

A reliable UV method was created to measure finasteride accurately.

research Inhibition of SARS-CoV-2 Entry Through the ACE2/TMPRSS2 Pathway: A Promising Approach for Uncovering Early COVID-19 Drug Therapies

77 citations, July 2020 in “European Journal of Clinical Pharmacology”

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

61 citations, April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

research Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice

28 citations, September 2019 in “International Journal of Nanomedicine”

Minoxidil nanoparticles can potentially be a more effective treatment for hair growth than current treatments.

research Iontophoresis of Minoxidil Sulphate Loaded Microparticles: A Strategy for Follicular Drug Targeting?

25 citations, July 2015 in “Colloids and Surfaces B: Biointerfaces”

Iontophoresis improves minoxidil delivery to hair follicles for hair loss treatment.

research Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the Ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine

23 citations, February 2015 in “International Journal of Molecular Sciences”

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

research Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

19 citations, November 2016 in “Dermatology and therapy”

Stopping the medication infliximab and starting new treatments helped a woman's hair grow back and improved her scalp condition.

research Photobiomodulation Therapy for Androgenetic Alopecia: A Clinician’s Guide to Home-Use Devices Cleared by the FDA

15 citations, October 2017 in “Journal of Cosmetic and Laser Therapy”

FDA-cleared devices may help treat hair loss, but more research needed; consult dermatologist before use.

research Assessing Dutasteride-Associated Sexual Dysfunction Using the U.S. Food and Drug Administration Adverse Event Reporting System

7 citations, December 2017 in “Journal of the European Academy of Dermatology and Venereology”

Dutasteride is linked to a higher chance of sexual dysfunction, especially in younger males and the elderly.

Development of Fast Reverse Phase Liquid Chromatographic Method for Simultaneous Analysis of Betamethasone Dipropionate and Calcipotriol in Ointments and Bulk Drug

research Development of Fast Reverse Phase Liquid Chromatographic Method for Simultaneous Analysis of Betamethasone Dipropionate and Calcipotriol in Ointments and Bulk Drug

5 citations, January 2014 in “Asian Journal of Chemistry”

Researchers developed a quick and reliable method to test for betamethasone dipropionate and calcipotriol in ointments and drugs.

Association of Melanoma and Nonmelanoma Skin Cancer with Antihypertensive Drugs: A Report from the Research on Adverse Drug Events and Reports Project

research Association of Melanoma and Nonmelanoma Skin Cancer with Antihypertensive Drugs: A Report from the Research on Adverse Drug Events and Reports Project

1 citations, April 2016 in “Journal of The American Academy of Dermatology”

Blood pressure medications may increase the risk of skin cancer.

Corrigendum to Patients Treated for Male Pattern Hair Loss With Finasteride Show, After Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma

research Corrigendum to Patients Treated for Male Pattern Hair Loss With Finasteride Show, After Discontinuation of the Drug, Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma

September 2023 in “The Journal of Steroid Biochemistry and Molecular Biology”

Stopping finasteride for male pattern hair loss changes neuroactive steroid levels in the brain and blood.

A Proposed Etiopathology of Persistent Dysfunctions Emerging from Use and Discontinuation of 5-Alpha Reductase Inhibitors: Sequelae of Drug-Mediated Microvasculopathy

research A Proposed Etiopathology of Persistent Dysfunctions Emerging from Use and Discontinuation of 5-Alpha Reductase Inhibitors: Sequelae of Drug-Mediated Microvasculopathy

February 2022

The document suggests that drugs for prostate issues might cause lasting sexual, mental, and physical health problems due to blood vessel damage in the penis.

Possible Contributory and Protective Factors in Medication Associated Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System

research Possible Contributory and Protective Factors in Medication Associated Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System

April 2020 in “Sleep”

Some drugs may increase the risk of obstructive sleep apnea, while others like certain biologics might decrease it.

research Microscopic Evaluation, Ethnobotanical and Phytochemical Profiling of a Traditional Drug Viola Odorata L. from Pakistan

January 2023 in “Ethnobotany Research and Applications”

research Is Finasteride Intake Associated with Penile Curvature/Peyronie’s Disease? Assessment of Both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) Pharmacovigilance Databases

October 2021 in “European urology open science”

research Finasteride Use Is Associated with Higher Odds of Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System

May 2020 in “Skinmed”

Finasteride use is linked to a higher risk of obstructive sleep apnea.

research Finasteride Use Is Associated with Higher Odds of Obstructive Sleep Apnea: Results from the US Food and Drug Administration Adverse Events Reporting System

January 2020 in “PubMed”

Finasteride use is linked to a higher risk of obstructive sleep apnea.

research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations, January 2022 in “International Journal of Molecular Sciences”

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Post-Screening Follow-Up of the Finnish Prostate Cancer Screening Trial on Putative Prostate Cancer Risk Factors: Vitamin and Mineral Use, Male Pattern Baldness, Pubertal Development, and Non-Steroidal Anti-Inflammatory Drug Use

research Post-Screening Follow-Up of the Finnish Prostate Cancer Screening Trial on Putative Prostate Cancer Risk Factors: Vitamin and Mineral Use, Male Pattern Baldness, Pubertal Development, and Non-Steroidal Anti-Inflammatory Drug Use

29 citations, February 2016 in “Scandinavian journal of urology”

Late puberty may slightly lower prostate cancer risk, baldness is not linked to overall risk but less so with aggressive types, ibuprofen use may increase risk, and vitamins show no effect on risk.

research Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

15 citations, December 2021 in “Pharmaceutics”

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

research Development Studies of Cuticle Drugs from Natural Resources: Effects of Crude Drug Extracts on Hair Growth in Mice

12 citations, January 1988 in “YAKUGAKU ZASSHI”

The study investigated the effects of 50% ethanol extracts from 14 crude drugs on hair regrowth in mice with removed abdominal hair. It found that extracts from Polygonum multiflorum (I), Drynaria fortunei (II), Panax japonicum (VII), and Swertia japonica (XI) promoted hair regrowth in normal mice. Additionally, extracts I and VII were effective in mice pretreated with a high butter diet. These findings suggested that extracts I and VII could be used as hair tonics to promote hair regrowth.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations, January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

Tolerability of Hair Cleansing Conditioners: A Double-Blind Randomized Controlled Trial Evaluating Consumer Complaints to the U.S. Food and Drug Administration

research Tolerability of Hair Cleansing Conditioners: A Double-Blind Randomized Controlled Trial Evaluating Consumer Complaints to the U.S. Food and Drug Administration

4 citations, March 2020 in “Cutaneous and ocular toxicology”

Wen by Chaz Dean Sweet Almond Mint Cleansing Conditioner is better tolerated than salicylic acid and baby shampoos.

Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

research Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

3 citations, April 2023 in “Frontiers in Pharmacology”

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

research Oral Contraceptive Pill Treatment Alters Gene Expression of Inflammatory Markers in Polycystic Ovary Syndrome Women

2 citations, February 2023 in “BMC women's health”

Birth control pills change the activity of certain inflammation and blood clotting genes in women with PCOS.

Real-World Effectiveness, Safety, and Tolerability of Cetosomal Minoxidil 5% Alone and in Combination With Finasteride 0.1% in the Management of Androgenetic Alopecia

research Real-World Effectiveness, Safety, and Tolerability of Cetosomal Minoxidil 5% Alone and in Combination With Finasteride 0.1% in the Management of Androgenetic Alopecia

1 citations, July 2023 in “Cureus”

Cetosomal minoxidil alone and with finasteride is effective and well-tolerated for hair loss treatment.

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