A Response to 'Inconsistent Platelet-Rich Plasma Product from the Food and Drug Administration Cleared Devices: A Retrospective Review of Clinic Data'

The response to the study on platelet-rich plasma (PRP) highlighted several factors that could account for inconsistent platelet counts in PRP products, such as the volume of whole blood used and the specific preparation methods. The authors noted that the original study did not specify the amount of whole blood drawn or whether platelet-poor plasma was removed, both of which affect PRP concentration. Additionally, the type of hematology analyzer used for platelet counting was not mentioned, which is crucial as many analyzers are calibrated for whole blood and may not accurately count PRP. The response emphasized the importance of considering these variables when comparing PRP preparation systems, especially for dermatologic applications like treating alopecia, where minimizing inflammatory cells is beneficial.