Medications Most Commonly Associated with Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database

    April 2022
    Elie Kaplan-Marans, Mariela Martinez, Arshia Sandozi, Jeffrey E. Lee, Jacob B. Khurgin, Ariel Schulman
    TLDR Certain medications, especially 5-alpha reductase inhibitors, are commonly linked to erectile dysfunction.
    The study utilized the FDA Adverse Event Reporting System (FAERS) to identify medications most frequently associated with erectile dysfunction (ED) from 2010-2020, excluding treatments for ED like phosphodiesterase-5 inhibitors and testosterone. Among the top 20 medications, 5-alpha reductase inhibitors (5-ARIs) had the highest frequency of ED reports, with 2,823 out of 6,142 total reports (46%). Finasteride and dutasteride showed the highest proportional reporting ratios (PRRs) of 110.03 and 9.40, respectively. Other medications associated with ED spanned various medical fields, including psychiatry, neurology, cardiology, dermatology, and immunology. The findings highlight the importance for physicians and patients to be aware of medications that may cause ED.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community British tabloid dutasteride fear mongering

      in Chat  103 upvotes 9 months ago
      The conversation discusses the impact of hair loss treatments like dutasteride and finasteride, with some users expressing skepticism about media claims linking these drugs to severe side effects like suicidal ideation. Many participants criticize the media, particularly British tabloids, for fearmongering and emphasize the psychological impact of hair loss itself.

      community Fresh off the press: Dutasteride may cause chronic infertility

      in Research/Science  643 upvotes 11 months ago
      Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  80 upvotes 2 years ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Finasteride won’t make all your problems go away

      in Finasteride/Dutasteride  323 upvotes 2 years ago
      A user shared that while finasteride improved their hair, it didn't solve all their insecurities, suggesting that self-acceptance is key. Others in the conversation expressed varying opinions, with some feeling that finasteride significantly boosted their confidence and quality of life, while others acknowledged it as a solution to hair loss but not a cure-all for other personal issues.

      community Does CosmeRNA target the root cause of MPB?

      in Chat 2 years ago
      . CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

    Similar Research

    6 / 1000+ results