182 citations,
November 2017 in “Molecular Aspects of Medicine” The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
42 citations,
November 2018 in “Archives of dermatological research” Apremilast was not effective in treating moderate-to-severe alopecia areata.
8 citations,
May 2019 in “Journal of dermatological treatment” Vismodegib is effective for basal cell carcinoma but has severe side effects.
June 2024 in “Journal of cosmetic dermatology” Dutasteride is the most studied alternative drug for androgenetic alopecia, but more high-quality research is needed.
The research found how certain drugs and polymers form stable complexes, which could help develop new pharmaceutical forms.
August 2023 in “Journal of controlled release” STAR particles can improve the effectiveness of topical hair growth treatments without causing skin irritation.
January 2017 in “Brazilian Journal of Pharmaceutical Sciences” Arteannuin might work against cancer and Alzheimer's by targeting neprilysin.
January 2012 in “Elsevier eBooks” Hair loss can cause emotional and social issues, and various treatments, including medication, surgery, and psychological support, are needed.
355 citations,
January 2017 in “Journal of the American Academy of Dermatology” JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.
Maidenhair fern extract may help treat COVID-19 symptoms.
10 citations,
January 2019 in “Biomarker Insights” Scalp cooling to prevent hair loss from chemotherapy works for some but not all, and studying hair damage markers could improve prevention and treatment.
May 2024 in “Brazilian Journal of Hair Health” Finasteride-loaded nanoparticles were successfully created for potential improved hair growth treatment.
October 2023 in “Georgetown medical review” Finasteride and Dutasteride can improve hair growth in male baldness but may cause temporary sexual dysfunction and possibly affect fertility.
211 citations,
May 2013 in “Journal of Nutrition Health & Aging” MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.
15 citations,
October 2017 in “Journal of Cosmetic and Laser Therapy” FDA-cleared devices may help treat hair loss, but more research needed; consult dermatologist before use.
1 citations,
June 2017 in “International Journal of Toxicology” Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
54 citations,
June 2020 in “Pharmaceutics” New nanocarriers improve drug delivery for disease treatment.
18 citations,
July 2009 in “Drug Metabolism and Disposition” Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.
15 citations,
November 2017 in “Drug Development and Industrial Pharmacy” Improved tablets lead to faster, better drug absorption for hair loss treatment.
50 citations,
July 2021 in “Nature Communications” The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.
6 citations,
August 2019 in “Indian drugs” Ethosomes improve drug delivery through the skin and show promise for treating male pattern baldness.
4 citations,
September 2012 in “Clinical Pharmacology in Drug Development” Different drug doses approved in Japan and the U.S. are not mainly due to different clinical responses, and ethnic factors should be considered in setting drug doses.
2 citations,
November 2019 in “Skin appendage disorders” Platelet-rich plasma doesn't prevent hair loss from chemotherapy, and mononuclear cells only help against hair loss from one specific chemotherapy drug.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” Non-drug therapies show promise for hair regrowth but need more research.
Off-label drug use can be risky but sometimes beneficial when standard treatments fail.
42 citations,
January 2021 in “Journal of Clinical Medicine” Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.
42 citations,
January 2019 in “Frontiers in Immunology” A blood pressure drug, diltiazem, may also help treat influenza.
40 citations,
March 2019 in “Pharmaceutical development and technology” Smaller particles of the drug carrier penetrated skin better, with 300 nm size being best for targeting hair follicles.
8 citations,
August 2018 in “International Journal of Dermatology” The document concludes that doctors should carefully consider off-label drug use in dermatology and always inform patients, while more research is needed on the safety and effectiveness of such practices.
3 citations,
June 2023 in “Journal of cosmetic dermatology” A new drug, abrocitinib, helped a child with severe hair loss regrow hair.