Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that PDGF-BB affects human melanocytes differently depending on their differentiation stage, stimulating melanoblast proliferation but inhibiting melanocyte proliferation while promoting their differentiation.

In this study, oral calcium pantothenate was associated with improvement in the inflammatory phase of discoid lupus erythematosus of the scalp, with the most marked response observed in subacute cases.

This study found that CPA-loaded nanoparticles, particularly SLN formulations, increased CPA epidermal penetration compared to a conventional cream and may reduce side effects in treating androgen-dependent conditions.

In this case report, a 22-year-old female was diagnosed with follicular Dowling-Degos disease based on clinical and histological findings, with symptoms including skin lesions confined to hair follicles. The report emphasizes the importance of differentiating this rare variant from similar conditions for proper management.

This case study reports successful regression of alopecia areata in a female patient through DPCP immunotherapy supported by oral antihistamines and topical corticosteroids, suggesting indirect antihistamine effects on allergic inflammation may contribute to improvement.

This study found that a significant portion of alopecia areata patients achieved at least partial hair regrowth with diphenylcyclopropenon therapy, which was more effective in certain subtypes and disease durations.

This article reviews the genetic and phenotypic characteristics of Trichothiodystrophy and discusses the associated DNA repair defects, but does not report new clinical findings.

This study showed that treating mouse fibroblasts with TTNPB can efficiently convert them into dermal-papilla-cell-like cells with strong hair-inducing capacity, suggesting potential for hair follicle regeneration therapies.

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets.

This case report describes a 30-year-old Brazilian male who developed vitiligo lesions following diphencyprone therapy for alopecia areata.

In this study, researchers found that certain cytokines can significantly down-regulate PDGF expression in dermal papilla cells and follicular keratinocytes, indicating a potential link between PDGF signaling and catagen induction.

This abstract is a listing of affiliations and funding, with no new study or results reported.

In this clinical trial, patients with lichen planopilaris treated with the oral TYK2 inhibitor deucravacitinib showed significant improvement in PGA, LPPAI, and Skindex-16 scores over 24 weeks, with transcriptomic analyses indicating decreased inflammatory and immune pathway activity post-treatment.

This study tested a folate-conjugate drug delivery system and found its cytotoxicity depends on whether the treated cells overexpress folate receptors, suggesting potential for targeted chemotherapy.

This study found that dermal papilla cell-conditioned medium can protect against UV-induced skin aging in a mouse model by modulating ferroptosis pathways, highlighting its potential for treating oxidative stress-related skin conditions.

This study found that oral paclitaxel combined with encequidar improved tumor response rates compared to intravenous paclitaxel in women with metastatic breast cancer, while also reducing neuropathy but increasing certain gastrointestinal and neutropenic side effects.

This study found that the cytoplasmic dynein component Dynlt3 is essential for effective melanosome transport and transfer in mouse melanocytes, linking melanosome positioning and acidity to the Wnt/β-catenin signaling pathway.

In this case series, dual-targeted therapy was observed to provide promising clinical responses in refractory inflammatory bowel disease, with 88.23% to 100% response rates across 9 months and an endoscopic response in 88.89% of evaluated patients, though some adverse events occurred.

This study concluded that adding 5% topical Procapil to PRP therapy provided better outcomes for androgenetic alopecia than PRP alone, as assessed by dermatologist evaluations and patient satisfaction.

This study suggests that the expression of the DP2 receptor is higher in balding scalp cells and that its knockdown could inhibit the transition to the catagen phase in cultured human hair follicles, potentially counteracting hair growth inhibition associated with male pattern baldness.

In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.

This study indicates that individuals exposed to PPD mount varying immune responses, with either tolerance, subclinical inflammation, or allergy, suggesting no true non-responders to PPD.

This review discusses current treatments for discoid lupus erythematosus and highlights anifrolumab as a promising option for difficult cases, but no new clinical results are reported.

This study suggests that DcR3 can reprogram macrophages towards a reparative state, enhancing wound healing and hair follicle regeneration, making it a potential target for treating chronic wounds and alopecia.

Cone beam computed tomography can allow for smaller safety margins around the target area in prostate cancer radiation treatment if used for ongoing treatment checks.

This study reports that platelet-rich plasma therapy resulted in temporary hair growth in patients with stabilized Central Centrifugal Cicatricial Alopecia.

This study observed that cultured dermal papilla cells showed distinct functional properties from dermal fibroblasts, including lower proliferation rates, higher adhesion to collagen type IV, and different cell-matrix interactions.

This study suggests that alkaline phosphatase-regulated expression of CCL5 contributes to the trichogenicity of human dermal papilla spheres.