Open-Label, Randomized, Multicenter, Phase III Study Comparing Oral Paclitaxel Plus Encequidar Versus Intravenous Paclitaxel in Patients With Metastatic Breast Cancer

    July 2022 in “ Journal of Clinical Oncology ”
    Hope S. Rugo, Gerardo Umanzor, Feliciano Barrios, Rosa H. Vasallo, Marco A. Chivalan, Suyapa Bejarano, J. Ramírez, Luis Fein, Rubén Dario Kowalyszyn, E Douglas Kramer, Hui Wang, Min-Fun Rudolf Kwan, David L. Cutler
    TLDR Oral paclitaxel plus encequidar improved tumor response and caused less neuropathy but more serious infections than intravenous paclitaxel.
    The study compared oral paclitaxel plus encequidar (oPac + E) to intravenous paclitaxel (IVpac) in 402 women with metastatic breast cancer. Results showed that oPac + E had a higher confirmed tumor response rate (36% vs. 23%) and longer median progression-free survival (8.4 months vs. 7.4 months) compared to IVpac. Overall survival was also longer for oPac + E (22.7 months vs. 16.5 months). While both treatments had similar rates of grade 3-4 adverse reactions, oPac + E had lower rates of neuropathy and alopecia but higher rates of gastrointestinal toxicity and neutropenic complications. The study concluded that oPac + E increased tumor response and had less neuropathy but more serious infections compared to IVpac.
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