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GlossaryNerve Damage (Neuropathy)

injury or dysfunction of nerves causing pain or numbness

Nerve damage, also known as neuropathy, refers to injury or dysfunction of the nerves, which can result in symptoms such as pain, numbness, tingling, or weakness. This condition can be caused by various factors including physical trauma, infections, metabolic issues like diabetes, or exposure to toxins. Effective diagnosis and treatment often require a multidisciplinary approach involving neurology, physical therapy, and sometimes surgery.

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research PIK3CA Gain-Of-Function Mutation In Schwann Cells Leads To Severe Neuropathy And Aerobic Glycolysis Through A Non-Cell Autonomous Effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

research Minoxidil Is a Potential Neuroprotective Drug for Paclitaxel-Induced Peripheral Neuropathy

28 citations , March 2017 in “Scientific Reports”

Minoxidil may protect nerves and improve hair quality during paclitaxel treatment.

research Clinical Case Notes: Tamoxifen Optic Neuropathy

23 citations , February 2004 in “Clinical and Experimental Ophthalmology”

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

research Mitochondrial Dysfunction in Diabetic Neuropathy May Be Involved in the Development of Neuropathic Pain via a Reduction in Neurosteroid Synthesis

4 citations , April 2017 in “F1000Research”

Mitochondrial problems in diabetic nerve damage might cause pain by lowering the production of certain nerve-related steroids.

research Peripheral Neuropathy Associated with Tofacitinib Use in Alopecia Universalis

1 citations , August 2022 in “Journal of Dermatology and Dermatologic Surgery”

A patient developed nerve problems as a side effect of a hair loss treatment called tofacitinib.

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community New 2025 study: high dose oral minoxidil (up to 10mg)

in Research/Science 80 upvotes 1 month ago

High-dose oral minoxidil (>5 mg/day) can increase hair density in some men with androgenetic alopecia, but side effects like extra body hair and heart issues are common. Gradual dose increase is advised, but adverse effects may lead to discontinuation or dose adjustments.

community P5P supplementation for fin sides.

in Treatment 7 upvotes 3 years ago

P5P supplementation helped reverse finasteride side effects, particularly by lowering prolactin levels and restoring sensitivity. The user experienced significant improvement within a day and full recovery in a few days.

community I'm quitting finasteride after almost 3 years of daily use

in Finasteride/Dutasteride 165 upvotes 1 month ago

A 23-year-old stopped using finasteride due to sexual side effects after three years. The discussion covers experiences with finasteride, dutasteride, and other treatments, noting varied side effects and effectiveness.

community Scientists May Have Accidentally Found a Way to Reverse Hair Loss Without Drugs

in Research/Science 879 upvotes 4 months ago

2-deoxy-D-ribose is being explored as a hair loss treatment but is not proven effective in humans and may be costly and inconvenient. Minoxidil remains the most effective treatment.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 1 year ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

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