Jockeys using diuretics without potassium supplements can face health problems.
May 2008 in “Trends in Urology Gynaecology & Sexual Health” This study found that continuous use of loop diuretics may double the rate of bone loss in elderly men compared to intermittent or non-use.
43 citations
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May 1978 in “JAMA” Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
1 citations
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January 1976 in “Clinical Science” This study concluded that minoxidil combined with a diuretic may effectively reduce blood pressure in moderately hypertensive male patients with minimal side effects.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone, a potassium-sparing diuretic with antiandrogenic activity, effectively improves hair density, reduces shedding, and stabilizes symptoms in female pattern hair loss, though symptoms often recur after discontinuation, suggesting the need for sustained therapy.
6 citations
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April 2013 in “Journal of Investigative Dermatology” This study reports that spironolactone use was associated with a decreased risk of developing rosacea compared to other diuretics, particularly in current users without previous androgenic skin disease diagnoses.
12 citations
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December 2023 in “Journal of Applied Pharmaceutical Sciences and Research” In this research, caffeine's versatile pharmacological actions were highlighted, demonstrating its stimulant, bronchodilator, diuretic, and potential anticancer effects through interactions with adenosine receptors, phosphodiesterase, and renal tubules, revealing valuable insights for drug development and therapeutic applications in medicine.
November 2024 in “International Society of Hair Restoration Surgery” This study investigated adverse events from low-dose systemic minoxidil in an older population with hair loss and found that 19% experienced mainly facial and body hypertrichosis, managed with interventions like dose reduction and diuretics; no serious adverse events occurred.
This study investigated the phytochemicals in Phyla nodiflora leaf extracts and identified n-Hexadecanoic acid, stigmasterol, and beta-sitosterol as promising drug candidates for diabetes, alopecia, cancer, and anti-diuresis, advocating further research into these compounds.
November 2021 in “European Heart Journal Supplements” In this case report, a 29-year-old woman with systemic lupus erythematosus and an increased risk of thrombosis experienced improved right heart function following diuretics, anticoagulants, corticosteroids, and immunosuppressants treatment.
November 2021 in “European Heart Journal Supplements” This case report describes a woman with systemic lupus erythematosus who developed chronic thromboembolic pulmonary hypertension, leading to improved right heart function after treatment with diuretics, anticoagulants, corticosteroids, and immunosuppressants.
December 2024 in “Plant Science Today” This study investigated the therapeutic potential of phytochemicals from Phyla nodiflora, identifying 50 bioactive compounds through GC-MS analysis. Among them, n-hexadecanoic acid, stigmasterol, and beta-sitosterol showed promise in molecular docking studies as drug candidates for diabetes, alopecia, cancer, and anti-diuresis.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone has shown effectiveness in improving hair density and reducing shedding in female pattern hair loss, particularly for women with hyperandrogenism, though benefits often diminish after stopping treatment.
This paper reviews the current evidence regarding the off-label use of spironolactone for acne management, noting that despite its long-standing application in acne treatment, it has not yet received FDA approval for this indication.
July 2020 in “Journal of the American Academy of Dermatology” This analysis found that spironolactone use is not associated with an increased risk of breast cancer recurrence in female survivors.
24 citations
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January 2014 in “The American Journal of Chinese Medicine” This review compiles data on Platycladus orientalis leaves, noting their diverse pharmacological activities and advocating for more research to clarify their traditional blood-cooling and hematostatic uses.
19 citations
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May 1979 in “Archives of internal medicine” Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
9 citations
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April 2011 in “PubMed” This review discusses spironolactone's dermatologic applications, particularly for conditions like hirsutism and female pattern hair loss, but reports no new results; it also highlights safety concerns in pregnancy and men.
1 citations
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September 2022 in “Molecules” This review systematically summarizes the chemical components and pharmacological research on Fructus Malvae, aiming to enhance its development and application in traditional Chinese medicine; it reports no new clinical results.
40 citations
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July 2011 in “The journal of clinical hypertension” This article reviews the use of hydralazine, minoxidil, and sodium nitroprusside in managing hypertension and hypertensive crises, noting specific indications, adverse effects, and the adjunctive therapies needed to mitigate side effects.
26 citations
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June 1983 in “Journal of Hypertension” Minoxidil lowers blood pressure more effectively but has more side effects, so try hydralazine first.
22 citations
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July 2010 in “Drug Testing and Analysis” This study presents a rapid method for detecting multiple xenobiotics in urine, effectively identifying 45 compounds banned in sports with detection limits below WADA's performance levels.
21 citations
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March 1982 in “JAMA” This study found that spironolactone at 200 mg/day effectively reduced facial hair growth in women with moderate to severe hirsutism, with improvements observed within two months and sustained over one year.
19 citations
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July 2006 in “Acta crystallographica” This study determined that previous reports mistakenly identified different polymorphs of furosemide and finasteride, which are actually identical, due to incomplete data collection in single-crystal X-ray diffraction analysis.
18 citations
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January 1976 in “Clinical Science” This study found that minoxidil significantly reduced supine diastolic pressure in 94% of patients with severe essential hypertension within 4 weeks, but some patients experienced side effects such as increased hair growth and fatigue.
16 citations
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March 1981 in “PubMed” This study found that minoxidil significantly reduced blood pressure in patients with intractable hypertension and was generally well-tolerated, although fluid retention and hirsutism posed some challenges.
11 citations
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June 2024 in “Molecules” This review investigated the phytochemical variations in different medicinal parts of the plant *Alpinia zerumbet*, finding distinct chemical compositions between leaves, rhizomes, fruits, seeds, and flowers, which supports the traditional use of these parts for various medicinal purposes.
11 citations
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March 2007 in “Journal of Hypertension” This article provides contact information for Professor A. Brew Atkinson and reports no new research findings; it is not a study abstract.
6 citations
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April 2010 in “International Journal of Advances in Scientific Research” This article reviews the traditional uses, active compounds, and potential medicinal properties of Wedelia biflora and Wedelia chinesis, particularly focusing on their anti-inflammatory and wound healing activities, but reports no new experimental results.
5 citations
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November 2014 This review discusses various potential pharmacological activities and traditional uses of Musa paradisiaca and M. sapientum but reports no new clinical results, highlighting the need for further scientific justification of their effects.