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This review in SEDA Volume 40 summarizes new adverse reaction data for diuretics published in 2017, highlighting specific risks such as fractures with loop diuretics and hyperkalemia with spironolactone.

Diuretics help the body get rid of excess salt and water by acting on the kidneys in different ways.

Mannitol diuresis allows higher doses of cis-platinum for testicular cancer treatment without increasing kidney damage.

This case report discusses an 80-year-old man whose hyponatremia likely resulted from multiple causes, including diuretic use, excessive water intake, and urinary retention, emphasizing cautious management in older adults.

This article highlights the complexity of diagnosing hyponatremia in older adults, emphasizing the need to evaluate urinary tract obstruction, medication effects, and age-related changes rather than relying solely on spot urinary values.

This study found that spironolactone enhanced the effectiveness of non-DNA-damaging cancer drugs gemcitabine and osimertinib in cancer cell lines and a mouse xenograft model, likely by suppressing the anti-apoptotic protein survivin.

This study reported that spironolactone at 200 mg/day significantly improved facial hair growth in women with hirsutism and showed a sustained reduction in ovarian androgens over one year.

This study observed that prolonged minoxidil treatment may improve renal function in some patients with refractory malignant hypertension, whereas the impact was mixed in patients with benign hypertension.

In this report, a 23-year-old woman developed nephrotic syndrome and was diagnosed with lupus nephritis after receiving the first dose of the AstraZeneca COVID-19 vaccine, but causation is not established.

Minoxidil, when used with a diuretic and β-blocking agent, can safely lower blood pressure in most children with severe hypertension due to kidney disease, with minimal side effects.

Caffeine becomes more toxic in rats when food intake is reduced by over 50%.

This case report discusses minoxidil-induced anasarca as a potential side effect in patients using minoxidil for hypertension, emphasizing the importance of recognizing it for early diagnosis and management.

This review evaluates traditional uses, phytochemical profiles, and pharmacological activities of Mediterranean Erica species, revealing the wide range of bioactive compounds and highlighting their antioxidant, anti-inflammatory, and antimicrobial activities. Further studies are suggested to fully understand their medicinal potential.

This article discusses the multifactorial nature of acne vulgaris, detailing its link to androgen-induced sebum production, altered keratinisation, inflammation, and bacterial colonisation, but reports no new research findings.

In this case report, a 14-year-old girl with nephrotic syndrome developed large edematous striae distensae due to high-dose steroid use and rapid body size increase from edema fluid accumulation.

This study suggests that the floral secretions of Brasiliorchis schunkeana may attract Diptera as potential pollinators, but field observations are needed to confirm this pollination syndrome.

This case report highlights that a patient developed pleural effusion due to unintentional oral use of topical minoxidil, despite not having chronic kidney disease.

This review discusses the integration of modern and Unani medicine in the management of Benign Prostatic Hyperplasia, highlighting the potential of Unani herbal formulations as promising alternatives with minimal side effects but reports no new clinical results.

This review highlights the potential benefits of Sowbhagya Chundi Legiyam, a Siddha herbal formulation containing Zingiber officinale, for supporting women's health during the puerperal period, suggesting it may strengthen the uterus and prevent diseases due to improper postnatal care.

This review found that oral minoxidil, used for treating androgenetic alopecia, can cause dose-dependent fluid retention and weight gain, but remains safe for most patients; a diuretic might be needed if significant weight gain occurs.

This review highlights the various nonmedical uses of anabolic androgenic steroids and associated polypharmacy, suggesting that preventing their abuse should be a public health priority, but it reports no new findings.

Spironolactone helps reduce hair growth in women with hirsutism but may cause menstrual irregularities.

This study suggests that combination drug therapy with spironolactone and either oral contraceptives or dexamethasone effectively manages unresponsive hirsutism, with eight of nine patients achieving satisfactory clinical responses.

This case report discusses an instance of cystitis caused by the chemotherapy drug Cytoxan, with no new findings reported.

This case report observed that despite treatment with Berlin blue and forced diuresis for thallium poisoning, a 42-year-old man experienced lasting distal polyneuropathy symptoms six months post-hospital discharge.

In this retrospective study, the incidence of hyperkalaemia within the first year of spironolactone use was assessed among women over 65 with female-pattern hair loss, highlighting a potential safety concern.

This source suggests that spironolactone, a potassium-sparing diuretic, is underutilized in dermatology despite evidence showing its potential benefits for female acne, hidradenitis suppurativa, and female androgenetic alopecia, noting its long-term safety and reduced need for additional testing in young women.

This abstract reviews the use of spironolactone as a treatment for hormonal acne, female pattern hair loss, and hirsutism due to its antiandrogenic properties and favorable side effect profile, highlighting its value in dermatological therapies.

This study showed that spironolactone effectively reduces morbidity and mortality in moderate to severe heart failure with reduced ejection fraction, but its benefits in heart failure with preserved ejection fraction are less clear.

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.