Spironolactone

    February 2024 in “ Practical Diabetes ”
    Sana Fatima, Andrea Llano, Gerry McKay
    Image of study
    TLDR Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.
    Spironolactone is a mineralocorticoid receptor antagonist and potassium-sparing diuretic with anti-androgenic properties. It is used for hypertension, primary hyperaldosteronism, heart failure, ascites, acne vulgaris, hirsutism, and female pattern hair loss. The RALES trial showed that treatment with 25mg spironolactone was associated with a 35% reduction in the risk of hospitalisation and 30% reduction in risk of death from cardiac causes in 1663 patients with moderate to severe heart failure. The PATHWAY-2 study found that spironolactone was effective in lowering blood pressure in patients with resistant hypertension. However, its role in patients with heart failure with preserved ejection fraction is less clear. It is also being investigated for its potential benefits in patients with diabetes and hypertension. Common side effects include hyperkalaemia and gynaecomastia.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 361 results

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 4 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

      community Spironolactone, what do you think?

      in Finasteride/Dutasteride  4 upvotes 5 months ago
      A user is considering Spironolactone for hair loss but is advised against it due to its effects on testosterone. Instead, they are recommended to try finasteride at 18 and consider dutasteride if needed.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 9 months ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Spironolactone topically with a try ?!

      in Research/Science  1 upvotes 11 months ago
      A 30-year-old male is considering using dutasteride and fluridil for hair loss maintenance and is curious about the effectiveness of topical spironolactone, as he cannot take finasteride. He is also planning a hair transplant.

      community Spironolactone or bicalutamide prescription

      in Treatment  4 upvotes 1 year ago
      The conversation is about someone seeking a doctor in the EU who prescribes spironolactone or bicalutamide for female pattern hair loss, as they are having difficulty finding treatment options beyond Minoxidil in Austria. They are asking for recommendations and are open to direct messages for assistance.

    Similar Research

    5 / 1000+ results