Spironolactone

    February 2024 in “ Practical Diabetes ”
    Sana Fatima, Andrea Llano, Gerry McKay
    Image of study
    TLDR Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.
    Spironolactone is a mineralocorticoid receptor antagonist and potassium-sparing diuretic with anti-androgenic properties. It is used for hypertension, primary hyperaldosteronism, heart failure, ascites, acne vulgaris, hirsutism, and female pattern hair loss. The RALES trial showed that treatment with 25mg spironolactone was associated with a 35% reduction in the risk of hospitalisation and 30% reduction in risk of death from cardiac causes in 1663 patients with moderate to severe heart failure. The PATHWAY-2 study found that spironolactone was effective in lowering blood pressure in patients with resistant hypertension. However, its role in patients with heart failure with preserved ejection fraction is less clear. It is also being investigated for its potential benefits in patients with diabetes and hypertension. Common side effects include hyperkalaemia and gynaecomastia.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 407 results

      community Spironolactone and pregnancy planning

      in Female  2 upvotes 2 weeks ago
      A user with AGA uses topical spironolactone 2% due to side effects from the oral form and is concerned about its use during conception and breastfeeding. They seek alternatives to prevent AGA relapse while planning pregnancy and after childbirth.

      community spironolactone pills to topical

      in Research/Science  6 upvotes 1 month ago
      Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.

      community Does the effect of spironolactone on androgenetic alopecia really weaken over time?

      in Female  4 upvotes 3 months ago
      Spironolactone can remain effective for a long time in treating androgenetic alopecia, but it may not completely stop hair loss. Hair loss treatments like spironolactone, finasteride, and dutasteride slow down hair loss rather than cure it, and their effectiveness can vary based on individual response and the aggressiveness of the condition.

      community Spironolactone VS dutasteride for female pattern hair loss

      in Treatment  7 upvotes 8 months ago
      Spironolactone is more potent and lowers testosterone and DHT, while dutasteride only impacts DHT. For female hair loss, checking hormones and considering treatments like oral minoxidil, spironolactone, or topical minoxidil is recommended.

    Similar Research

    5 / 1000+ results