TLDR Minoxidil can cause severe body swelling and fluid buildup, which improves after stopping the drug and using diuretics.
This case report described a 70-year-old male with uncontrolled hypertension who developed generalized anasarca and pleuropericardial effusion while on minoxidil 10 mg twice daily. The patient presented with symptoms including body swelling, extremity pain, dyspnea, and abdominal distention. Physical examination revealed jugular vein pressure, lung crackles, abdominal distention, and pitting edema. Laboratory and imaging findings confirmed pericardial and pleural effusion, abdominal ascites, and anasarca. Discontinuation of minoxidil and initiation of intravenous diuretics led to clinical improvement. The report highlighted the importance of considering minoxidil-induced anasarca as a differential diagnosis in patients using this medication.
110 citations
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August 2016 in “Drugs” Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.
74 citations
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May 2004 in “Journal of Clinical Hypertension” Minoxidil effectively treats severe hypertension, but watch for side effects.
16 citations
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May 1982 in “Postgraduate Medical Journal” Minoxidil can cause pericardial and pleural effusions with high protein content.
August 2023 in “Journal of Cosmetic Dermatology” Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.
8 citations
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April 2019 in “Dermatologic Therapy” Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.
5 citations
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January 2018 in “Italian journal of dermatology and venereology” Minoxidil effectively stimulates hair growth in androgenetic alopecia.
269 citations
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August 2002 in “Journal of The American Academy of Dermatology” 5% minoxidil works better for hair growth and density, with minor irritation.
39 citations
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March 1987 in “Journal of The American Academy of Dermatology” Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.
20 citations
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February 1985 in “Archives of Dermatology” Minoxidil helps hair regrowth, especially with more indeterminate hairs.
