9 citations
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June 2020 in “Actas Dermo-Sifiliográficas” This source suggests that spironolactone, a potassium-sparing diuretic, is underutilized in dermatology despite evidence showing its potential benefits for female acne, hidradenitis suppurativa, and female androgenetic alopecia, noting its long-term safety and reduced need for additional testing in young women.
This abstract reviews the use of spironolactone as a treatment for hormonal acne, female pattern hair loss, and hirsutism due to its antiandrogenic properties and favorable side effect profile, highlighting its value in dermatological therapies.
February 2024 in “Practical Diabetes” This study showed that spironolactone effectively reduces morbidity and mortality in moderate to severe heart failure with reduced ejection fraction, but its benefits in heart failure with preserved ejection fraction are less clear.
102 citations
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September 1977 in “The Lancet” Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.
Jockeys using diuretics without potassium supplements can face health problems.
74 citations
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January 2014 in “Journal of Investigative Dermatology” High kallistatin levels in diabetics worsen wound healing by blocking important cell signals.
May 2008 in “Trends in Urology Gynaecology & Sexual Health” This study found that continuous use of loop diuretics may double the rate of bone loss in elderly men compared to intermittent or non-use.
43 citations
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May 1978 in “JAMA” Minoxidil controls blood pressure but may cause kidney damage and needs diuretics to prevent swelling.
1 citations
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January 1976 in “Clinical Science” This study concluded that minoxidil combined with a diuretic may effectively reduce blood pressure in moderately hypertensive male patients with minimal side effects.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone, a potassium-sparing diuretic with antiandrogenic activity, effectively improves hair density, reduces shedding, and stabilizes symptoms in female pattern hair loss, though symptoms often recur after discontinuation, suggesting the need for sustained therapy.
November 2021 in “World Family Medicine Journal /Middle East Journal of Family Medicine” This study observed that diabetic ketoacidosis is common among type-1 diabetics, particularly with initial disease presentation or treatment discontinuation, and is more frequent in females and those with less educated or related parents.
1 citations
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January 2019 in “International Journal of Advances in Medicine” This study found that infections were the most common skin issues in diabetics, especially among those with poorly controlled blood sugar.
November 2010 in “Value in Health” Using a call center to collect data in a trial for eye disease in diabetics led to high response rates and very little missing information.
6 citations
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April 2013 in “Journal of Investigative Dermatology” This study reports that spironolactone use was associated with a decreased risk of developing rosacea compared to other diuretics, particularly in current users without previous androgenic skin disease diagnoses.
January 2018 in “Springer eBooks” Terbinafine is the most effective medicine for fungal nail infections, especially for diabetics and those with weak immune systems.
Iron supplements may reverse premature graying in iron-deficient individuals; ingrown nails are common in diabetics with certain risk factors; topical finasteride may reduce scalp DHT as effectively as oral finasteride; monilethrix treatment is challenging but some medications can help.
November 2024 in “International Society of Hair Restoration Surgery” This study investigated adverse events from low-dose systemic minoxidil in an older population with hair loss and found that 19% experienced mainly facial and body hypertrichosis, managed with interventions like dose reduction and diuretics; no serious adverse events occurred.
This study investigated the phytochemicals in Phyla nodiflora leaf extracts and identified n-Hexadecanoic acid, stigmasterol, and beta-sitosterol as promising drug candidates for diabetes, alopecia, cancer, and anti-diuresis, advocating further research into these compounds.
November 2021 in “European Heart Journal Supplements” In this case report, a 29-year-old woman with systemic lupus erythematosus and an increased risk of thrombosis experienced improved right heart function following diuretics, anticoagulants, corticosteroids, and immunosuppressants treatment.
November 2021 in “European Heart Journal Supplements” This case report describes a woman with systemic lupus erythematosus who developed chronic thromboembolic pulmonary hypertension, leading to improved right heart function after treatment with diuretics, anticoagulants, corticosteroids, and immunosuppressants.
12 citations
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December 2023 in “Journal of Applied Pharmaceutical Sciences and Research” In this research, caffeine's versatile pharmacological actions were highlighted, demonstrating its stimulant, bronchodilator, diuretic, and potential anticancer effects through interactions with adenosine receptors, phosphodiesterase, and renal tubules, revealing valuable insights for drug development and therapeutic applications in medicine.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, the researchers reported that Chyavanaprasam K Tab, a novel Ayurvedic tablet, showed consistent quality and safety, offering potential benefits for fatigue relief, immune support, and hair growth, and is suitable for diabetics due to its sugar-free composition.
July 2022 in “International Journal of Health Sciences (IJHS) (En línea)” In this study, researchers found that serum dihydrotestosterone levels were significantly lower in individuals with Type 2 Diabetes compared to healthy controls, with 90% of diabetics displaying subnormal levels.
December 2024 in “Plant Science Today” This study investigated the therapeutic potential of phytochemicals from Phyla nodiflora, identifying 50 bioactive compounds through GC-MS analysis. Among them, n-hexadecanoic acid, stigmasterol, and beta-sitosterol showed promise in molecular docking studies as drug candidates for diabetes, alopecia, cancer, and anti-diuresis.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports that spironolactone has shown effectiveness in improving hair density and reducing shedding in female pattern hair loss, particularly for women with hyperandrogenism, though benefits often diminish after stopping treatment.
This paper reviews the current evidence regarding the off-label use of spironolactone for acne management, noting that despite its long-standing application in acne treatment, it has not yet received FDA approval for this indication.
July 2020 in “Journal of the American Academy of Dermatology” This analysis found that spironolactone use is not associated with an increased risk of breast cancer recurrence in female survivors.
January 2004 in “Weiliang yuansu yu jiankang yanjiu” This study found that diabetic individuals had significantly lower hair levels of chromium, manganese, and copper, but higher iron levels, compared to non-diabetic controls.
24 citations
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January 2014 in “The American Journal of Chinese Medicine” This review compiles data on Platycladus orientalis leaves, noting their diverse pharmacological activities and advocating for more research to clarify their traditional blood-cooling and hematostatic uses.
19 citations
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May 1979 in “Archives of internal medicine” Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.