Beyond Boundaries: The Transformative Potential of Spironolactone in Female Pattern Hair Loss

Spironolactone, a potassium-sparing diuretic with antiandrogenic properties, has shown promise as an effective treatment for Female Pattern Hair Loss (FPHL), a condition that significantly impacts psychological well-being. It works by inhibiting androgen receptors, suppressing 5-α reductase activity, reducing circulating androgens, and stabilizing the hair growth cycle. Clinical studies have reported improvements in hair density, reduced shedding, and disease stabilization, especially in women with hyperandrogenism. The treatment is generally well tolerated and cost-effective, but recurrence of hair loss is common after stopping the medication, highlighting the need for ongoing therapy. Future research should focus on optimizing dosing strategies and exploring long-term safety through larger trials.