The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

November 2020 in “ Journal of The American Academy of Dermatology ”

Brianna De Souza, Laura J. Burns, Sonya Prasad, Elizabeth Flynn, Dina Hagigeorges, Maryanne M. Senna

TLDR GSK-36 downregulation with UTMD improves plaque stability in atherosclerosis treatment.

This document is not related to hair loss, alopecia, or hair growth. It discusses a study on the use of ultrasound-targeted microbubble destruction (UTMD) technology for drug delivery and gene transfection in the treatment of atherosclerosis (AS). The study found that downregulation of GSK-36 expression via UTMD suppressed vulnerable plaque factors and inflammation in vitro and in vivo, changed the cytoskeleton of the foam cells in vitro, increased Young's modulus and decreased the peak intensity of atherosclerotic plaque in vivo. The study suggests that GSK-36 could be a potential target for anti-atherogenic interventions and can improve the stability of AS plaques in combination with UTMD.

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