Efficacy and Safety of Spironolactone in Acne Management

    April 2025 in “ Cutis ”
    Nikita Menta
    Studysummary This paper reviews the current evidence regarding the off-label use of spironolactone for acne management, noting that despite its long-standing application in acne treatment, it has not yet received FDA approval for this indication.
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    Research cited in this study 5

    1. Spironolactone Treatment for Dermatologic Indications Is Not Associated With Hypotension in a Single-Center Retrospective Study Journal of the American Academy of Dermatology · 2024
    2. Guidelines of Care for the Management of Acne Vulgaris Journal of the American Academy of Dermatology · 2024
    3. Association of Spironolactone Use With Risk of Cancer: A Systematic Review and Meta-Analysis JAMA Dermatology · 2022
    4. Trends in the Prescribing Pattern of Spironolactone for Acne and Hidradenitis Suppurativa in Adolescents Journal of The American Academy of Dermatology · 2021
    5. Spironolactone Use Does Not Increase the Risk of Female Breast Cancer Recurrence: A Retrospective Analysis Journal of The American Academy of Dermatology · 2020