Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reviews the potential of dibenzo derivatives as safer cancer treatments but finds conflicting evidence about their effectiveness, possibly due to structural differences among the compounds, and reports no new results.

This study found that the EtOAc extract of Tridax procumbens aerial parts significantly inhibited rat paw edema and COX enzyme activity, suggesting its potential anti-inflammatory properties.

This study explored the in vitro skin penetration of two compounds from Tectona grandis leaf extract used for standardization and found that compound 1 penetrates more efficiently than compound 2, especially with a propylene glycol enhancer.

This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.

This study investigated the cytotoxic effects of DHA derivatives on cancer cell lines and found that didocosahexaenoin was the most potent, inducing apoptosis and producing reactive oxygen species in PC3 prostate carcinoma cells.

This study identified seven compounds from Cercidiphyllum japonicum twig extracts, including a newly discovered flavonoid, marking the first time these specific compounds have been isolated from this genus.

This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.

This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.

This study found that essential oils from Hedychium spicatum showed anti-inflammatory, antinociceptive, antipyretic, and antioxidant activities, with site-specific variations in their effectiveness.

This study analyzed the ethanol extract of pacing tawar leaves and found it contains alkaloids, saponins, tannins, and steroids but not flavonoids, suggesting potential for use in natural medicinal products.

In this study, the wood essential oil of *Juniperus morrisonicola* exhibited significant anti-inflammatory activity, notably inhibiting nitric oxide production in stimulated macrophages, and showed cytotoxic effects against liver cancer cells, suggesting its potential for drug development and eco-friendly applications.

In this study, researchers isolated new compounds from the plant *Calanthe cardioglossa* and found that five of these compounds, particularly calancardin B, significantly reduced TNF-α levels in immune cells relevant to multiple sclerosis, suggesting potential for immunomodulatory effects.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

In this study, germacrone from Curcuma aeruginosa showed anti-androgenic effects by inhibiting 5α-reductase, suggesting its potential as a lead compound for treating androgen-dependent disorders.

This invention reports piperazine derivatives as potent inhibitors of type 3 17β-hydroxysteroid dehydrogenase, suggesting potential therapeutic applications in treating prostate cancer, acne, and androgenic alopecia.

This study found that ethanol and petroleum ether extracts of Tridax procumbens roots demonstrated significant antibacterial activity against various bacterial strains compared to benzene extracts.

In this study, the ethanol extract of Tridax procumbens leaves exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria, with specific active compounds identified through GC-MS analysis that may contribute to its therapeutic potential.

This study identified over 40 phytochemical compounds in the leaves and flowers of Bituminaria bituminosa, predominantly glycosylated flavonoids from apigenin, using advanced chromatographic techniques.

This theoretical study suggests that certain cannabinoid derivatives could potentially be effective as androgen receptor and 5α-reductase enzyme inhibitors, indicating they may be promising candidates for prostate cancer treatment based on their higher affinity to target proteins compared to standard drugs.

This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.

This in-silico study identified several compounds as potential Vitamin D Receptor agonists, with Dolichosterone showing the strongest binding energy.

This study found that compound 4 from Urtica triangularis subsp. pinnatifida exhibited stronger anti-BPH activity against BPH-1 cells with an IC50 of 79.75 μM compared to finasteride's IC50 of 91.8 μM, while compounds 1, 2, and 5 showed moderate activity.

This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.

This study identified various secondary metabolites such as terpenes, phenolic acids, and flavonoids in plants mentioned by Ibnu Sina for hair cosmetic applications.

This study successfully synthesized novel cercidin analogues from Cercidophyllum japonicum, confirming their structure via NMR data. The researchers suggest these compounds could facilitate future antibiotic development by advancing structure-activity-relationship studies.

This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.

This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.

This study found that Dysphania ambrosioides oil exhibited cytotoxicity against U-937 lymphoma cells, indicating potential activity that warrants further investigation.

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.