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research Formulation and Characterization of Transethosomes for Enhanced Transdermal Delivery of Propranolol Hydrochloride
This study found that transethosomal gel loaded with propranolol hydrochloride prolonged drug release and increased peak plasma concentration compared to an oral tablet, suggesting a promising alternative for delivery.
research Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris
This review found that metformin was an effective adjunct therapy for treating moderate-to-severe acne vulgaris in patients without polycystic ovary syndrome or androgen excess.
research Steroid 5α-reductase inhibition by polymethoxyflavones
This study found that among eleven tested polymethoxyflavones, 5-hydroxy-7,4′-dimethoxyflavone was the strongest steroid 5α-reductase inhibitor and suggests potential use for benign prostatic hyperplasia treatment.
research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier
This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.
research REKONDISI TRANSFORMATOR DISTRIBUSI DI UP BANDUNG
This study reported that a topical hair tonic containing a 7.5% talok leaf and 2% pare leaf extract combination promoted hair growth in female Wistar rats similarly to minoxidil, showing a 64.71% increase in hair growth with no significant difference from minoxidil in statistical analysis.
research Neoadjuvant therapy with Disitamab vedotin in treating muscle-invasive bladder cancer: A case report
In this study, a 68-year-old man with muscle-invasive bladder cancer and renal insufficiency achieved a partial radiological response to neoadjuvant therapy with gemcitabine and Disitamab Vedotin, without significant adverse events, highlighting a potential alternative for cisplatin-ineligible patients.
research Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma
This study observed that the toxicity of Doxil in metastatic breast carcinoma patients is both dose and schedule dependent, with clear correlations to pharmacokinetic parameters.
research Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity
This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia
In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.
research Enhanced Clinical Outcomes and Treatment Adherence in Patients Using Compounded Topical Minoxidil to Treat Androgenetic and Traction Alopecia.
This study found that compounded topical minoxidil was associated with higher adherence, fewer side effects, and more clinical improvement in Black women compared to over-the-counter minoxidil.
research Constructing transnational divas: Gendered production of Balkan Turbo-folk music
This study found that an adjusted dosing regimen of oral betamethasone led to complete hair regrowth in an 8-year-old with alopecia totalis, without observed side effects.
research 43755 Rapid Reduction and Strict Complete Response in Itch With Oral Difelikefalin in Subjects With Notalgia Paresthetica and Moderate-to-Severe Pruritus
This study found that in participants with notalgia paresthetica, 8 weeks of treatment with difelikefalin significantly improved itch intensity and increased the rate of strict complete response compared to placebo, starting as early as week 3.
research Dermatological medications and local therapeutics
This review discusses the safety of dermatological medications used during pregnancy, highlighting that retinoids have strong teratogenic risks and should be used with caution; it reports no new clinical results.
research Dienogest
In this study, oral dienogest combined with ethinylestradiol provided effective contraception with a Pearl Index of approximately 0.2 and improved androgenic symptoms without significant metabolic effects.
research Testosterone (T) secreting tumor or insulin resistance? metformin (M) as a diagnostic (Dx) and therapeutic (Rx) trial
This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.
research Dianabol Unveiled: A Systematic Review of Methandrostenolone
This source offers an in-depth review of Methandrostenolone, examining its pharmacology, performance-enhancing effects, potential health risks, and legal status in various countries, while emphasizing the scientific evidence surrounding its use and misuse.
research Simultaneous effects of tocopheryl polyethylene glycol succinate (TPGS) on local hair growth promotion and systemic absorption of topically applied minoxidil in a mouse model
This study found that incorporating 0.5% TPGS into topical minoxidil solutions enhanced hair growth in mice, although increasing TPGS to 2% decreased effectiveness.
research Dexmedetomidine-Loaded Hydrogel Microneedles Alleviate Acute Inflammatory Visceral Pain in Mice
This study found that Dex-loaded hyaluronic acid hydrogel microneedles significantly reduced pain in an acute inflammatory visceral pain model without sedation, suggesting a promising and patient-friendly alternative to intravenous delivery.
research Dimethylsiloxane polymers for the effective transdermal delivery of Minoxidil in hair loss treatment
This study reported that a new polymeric formulation for topical minoxidil delivery in an animal model improved hair growth and hair follicle formation more effectively than minoxidil in PBS, suggesting potential as a future hair loss treatment.
research Metformin/dopamine derived bioactive carbon dots accelerate bacteria‐infected wound healing
In this study, carbon dots derived from metformin and dopamine (MD‐CDs) effectively promoted healing in bacterial-infected wounds by inhibiting infection, expediting inflammation-to-healing transition, enhancing cell proliferation and migration, and fostering collagen deposition and hair follicle regeneration.
research Tacrolimus in Dermatologic Disorders
This review reports that topical tacrolimus appears to be a safe and effective short-term treatment for inflammatory skin disorders, though further study is needed to assess long-term safety and efficacy.
research Sacituzumab Govitecan-Hziy (Trodelvy™)
This study reports that sacituzumab govitecan achieved a 33.3% overall response rate in patients with metastatic triple-negative breast cancer who had prior treatments, with a median response duration of 7.7 months.
research Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes
This study found that Melamax®, originally developed as an eco-friendly hair dye, provides significant protection against ultraviolet-induced oxidative and inflammatory damage in keratinocytes by modulating gene expression and signaling pathways, highlighting its dual potential for cosmetic coloration and skin photoprotection.
research Profound bradycardia after addition of diltiazem to a beta blocker.
Adding diltiazem to a beta blocker can cause dangerously slow heart rates.
research A new catalyst for organic synthesis: mercuric triflate
This study describes Hg(OTf)2 as a new and efficient catalyst for various organic synthesis reactions, including alkyne hydration and C–C bond forming cyclizations.
research Diphenyl cresyl phosphate [MAK Value Documentations, 2003]
This paper discusses various toxicological properties of diphenyl cresyl phosphate, highlighting its low acute toxicity, potential neurotoxicity linked to o-cresyl phosphate content, and the lack of data for inhalation exposure, but presents no new experimental findings.
research Metformin and Malignant Tumors: Not Over the Hill
This research discusses the potential antitumor effects of metformin, a common diabetes medication, noting its controversial influence on different malignant tumors and its uncertain mechanisms. Understanding these effects on tumors may aid in the development of new cancer treatments.
research Comparative Efficacy Study Combination of Oral Methotrexate and Prednisolone versus Oral Methotrexate in Patients with Lichen Planopilaris
In this study, methotrexate therapy with or without corticosteroids showed similar efficacy and safety in treating patients with lichen planopilaris, with no significant differences in the primary outcome or adverse effects between the two groups.
research Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L.
This study found that the EtOAc extract of Tridax procumbens aerial parts significantly inhibited rat paw edema and COX enzyme activity, suggesting its potential anti-inflammatory properties.