Dimethylsiloxane Polymers for the Effective Transdermal Delivery of Minoxidil in Hair Loss Treatment
January 2025
in “
Biomedical Engineering Letters
”
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Studysummary This study reported that a new polymeric formulation for topical minoxidil delivery in an animal model improved hair growth and hair follicle formation more effectively than minoxidil in PBS, suggesting potential as a future hair loss treatment.
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The study introduces a new polymeric formulation, MXD@CP, using citric acid dimethylsiloxane polymer for the transdermal delivery of Minoxidil (MXD), a common hair loss treatment. This formulation aims to mitigate the side effects associated with oral MXD by enabling topical application. The MXD@CP was shown to effectively load MXD up to 5%, a clinically relevant concentration, and demonstrated superior hair growth and hair follicle formation in comparison to MXD@PBS. The results from animal studies suggest that MXD@CP could be a promising next-generation treatment for hair loss.
