Diphenyl Cresyl Phosphate [MAK Value Documentations, 2003]
April 2016
TLDR Diphenyl cresyl phosphate has low toxicity but can harm the liver, kidneys, adrenal glands, and testicles at high doses.
The document reviewed the toxicological profile of diphenyl cresyl phosphate, noting its low acute toxicity and minimal skin and eye irritation. Animal studies identified the liver, kidneys, and adrenal glands as target organs, with neurotoxic effects primarily due to the o-cresyl isomer. High doses caused reproductive toxicity and testicular damage in rats, but no genotoxic or teratogenic effects were observed. Neurotoxic symptoms such as ataxia and paralysis were dose-dependent, with significant inhibition of NTE activity. Human data were limited, and no MAK value was established due to insufficient inhalation exposure studies.
