The Acute Toxicity of 2,3,4,7,8-Pentachlorodibenzofuran (4PeCDF) in the Male Fischer Rat

    January 1988 in “ Toxicological Sciences ”
    David Brewster, L C Uraih, Linda S. Birnbaum
    TLDR 4PeCDF is highly toxic to male rats, causing weight loss, organ damage, and death.
    The study investigated the acute toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in male Fischer rats, revealing a dose-dependent loss of body weight and signs of toxicity such as piloerection, hair loss, hypoactivity, morbidity, and death. The LD50/35 was estimated at 916 μg/kg. Toxic effects included increased serum cholesterol, triglycerides, bile acids, and liver enzyme activities, along with decreased hematocrit and hemoglobin levels. Hepatotoxicity was marked by lipid accumulation and hepatocytomegaly, while thymic atrophy and lymphoid depletion were noted. The study suggested that 4PeCDF and TCDD might share similar biochemical mechanisms of toxicity.
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