The Acute Toxicity of 2,3,4,7,8-Pentachlorodibenzofuran (4PeCDF) in the Male Fischer Rat

    January 1988 in “ Toxicological Sciences ”
    David Brewster, L C Uraih, Linda S. Birnbaum
    TLDR 4PeCDF is highly toxic to male rats, causing weight loss, organ damage, and death.
    The study investigated the acute toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in male Fischer rats, revealing a dose-dependent loss of body weight and signs of toxicity such as piloerection, hair loss, hypoactivity, morbidity, and death. The LD50/35 was estimated at 916 μg/kg. Toxic effects included increased serum cholesterol, triglycerides, bile acids, and liver enzyme activities, along with decreased hematocrit and hemoglobin levels. Hepatotoxicity was marked by lipid accumulation and hepatocytomegaly, while thymic atrophy and lymphoid depletion were noted. The study suggested that 4PeCDF and TCDD might share similar biochemical mechanisms of toxicity.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 34 results

      community Hair Growth Journey: 10 months

      in Progress Pictures  252 upvotes 1 year ago
      A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

      community Do hair follicles dies or are dormant ?

      in Finasteride/Dutasteride  92 upvotes 1 year ago
      Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

      community I’m on a crazy hairloss stack and I’m still losing hair and not experiencing any regrowth. What is going on?

      in Treatment  33 upvotes 1 year ago
      The user is using a combination of hair loss treatments including finasteride, stemoxydine, oral minoxidil, RU58841, dermastamping, ketoconazole shampoo, collagen, Viviscal, and biotin, and has improved their diet. Despite these efforts, they are still experiencing hair shedding and scalp itchiness, and are considering increasing their minoxidil dosage or starting dutasteride.

      community Stop expecting results in 2 months!

      in Treatment  125 upvotes 1 year ago
      People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

    Similar Research

    5 / 122 results