76 citations
,
October 2019 in “Dermatology and Therapy” This review discusses the diagnosis, treatment, and management of atopic dermatitis in developing countries and identifies significant unmet medical needs, particularly in access to care and effective treatments; it reports no clinical results.
62 citations
,
September 1974 in “Academy of Management Journal” This article discusses the need for organizational scholars to shift focus from big business organizations to everyday events and places, but it reports no new empirical results.
61 citations
,
April 2012 in “British Journal of Dermatology” This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.
59 citations
,
July 2015 in “Journal of Immunology” This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.
56 citations
,
November 2016 in “Aesthetic surgery journal” This review discusses the varied use and inconsistent reporting of platelet rich plasma in aesthetic surgery, finding that current studies lack consistent methodologies and objective evidence, and reports no new clinical results.
55 citations
,
October 2019 in “Dermatology and therapy” This review found that JAK/STAT pathway inhibitors, such as tofacitinib and ruxolitinib, led to symptom improvement in all observed atopic dermatitis cases, but responses were mixed for vitiligo and alopecia areata, with a generally mild safety profile reported.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” This study examined different polymersome systems for topical finasteride delivery and found that chitosan-decorated C7 polymersomes may enhance skin retention and provide controlled drug release compared to non-decorated systems in laboratory settings.
50 citations
,
November 2010 in “Plastic and Reconstructive Surgery” This study suggests that Botox injections may increase hair count and reduce hair loss in men with androgenetic alopecia, potentially through increased blood flow and oxygen to the scalp.
45 citations
,
June 2004 in “Lasers in Medical Science” This study found that non-coherent intense pulsed light (IPL) treatment significantly reduced hair growth by about 80% in patients with skin type III-V without causing side effects.
39 citations
,
October 2013 in “Plastic and Reconstructive Surgery” In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.
34 citations
,
January 2020 in “IEEE Access” This study reported that the PM-DBiGRU model enhances aspect-level sentiment classification in drug reviews, outperforming existing methods on the newly proposed SentiDrugs dataset.
33 citations
,
August 2024 in “Frontiers in Drug Discovery” In this article, the authors describe how drug repurposing, supported by large-scale data and artificial intelligence, can make drug discovery more cost-effective and expedient compared to traditional methods, despite certain regulatory challenges.
33 citations
,
January 2022 in “Scientific Reports” This study found that loading CoQ10 into a protransfersomal emulgel improved its stability and anti-ageing effects in UV radiation skin-aged induced-mice, without causing skin irritation.
33 citations
,
November 2019 in “Journal of Controlled Release” In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.
33 citations
,
December 2012 in “NMR in Biomedicine” This study reports that microencapsulation of therapeutic cells with contrast agents enables visualization across multiple imaging modalities, potentially improving cellular immunoprotection and tracking after transplantation.
32 citations
,
June 2015 in “PLOS ONE” This study demonstrated that topical oleuropein induced hair growth in mice by activating the Wnt10b/β-catenin signaling pathway and increasing expression of several growth-related genes in skin tissue.
32 citations
,
January 2014 in “Dermatology Research and Practice” This study found that trichoscopy can rapidly and noninvasively diagnose tinea capitis and alopecia areata in pediatric patients by identifying specific hair patterns associated with each condition.
30 citations
,
March 2017 in “ACS biomaterials science & engineering” This review discusses the structure and regenerative potential of hair follicles, highlighting their role in wound healing, stem cell populations, and keratin-based biomaterials, but it reports no new clinical results.
30 citations
,
January 2008 in “The Aging Male” This study found no difference in male pattern baldness between patients with benign prostate hyperplasia and prostate cancer, and no correlation with serum androgen levels.
28 citations
,
January 2012 in “Case Reports in Medicine” This article discusses Hair-thread Tourniquet Syndrome in children, emphasizing the need for prompt examination and intervention to prevent severe complications, but reports no new clinical results.
26 citations
,
October 2023 in “Neuroscience Bulletin” In this review, the authors discuss how understanding and co-regulating multiple signaling pathways could lead to effective regeneration of functional hair cells, highlighting current achievements and future approaches such as small molecule drugs and gene therapy for treating sensorineural hearing loss.
26 citations
,
August 2020 in “Dermatology Research and Practice” This review discusses the various skin manifestations and problems related to COVID-19 and associated treatments, but it reports no new clinical findings.
26 citations
,
May 2019 in “PLOS ONE” This study observed that hair follicles in hair loss patients had increased levels of Propionibacterium acnes, potentially linked to elevated immune response gene expression in miniaturized hair follicles.
26 citations
,
April 1999 in “Dermatologic Clinics” This article reviews the basics of hair follicle biology, laser/tissue interactions, and hirsutism and hypertrichosis causes, discussing the long-pulsed alexandrite laser's role in hair reduction without reporting new clinical results.
25 citations
,
September 2014 in “Dermatologic Surgery” This study found that hair transplantation using round grafts improved hair growth in African American women with end-stage CCCA, showing no postoperative scarring in the donor or recipient areas.
25 citations
,
January 2019 in “Annals of Dermatology” This study observed that the NOTCH signaling pathway may contribute to the development of fibrosis in systemic sclerosis by affecting epithelial cell changes, and inhibiting this pathway could prevent fibrosis in experimental models.
24 citations
,
September 2020 in “Dermatology and therapy” This study found that low-dose oral minoxidil 5 mg daily significantly increased hair growth in men with androgenetic alopecia over 24 weeks, with increased hair count and vertex area improvement, though most experienced hypertrichosis and some had pedal edema.
24 citations
,
January 2015 in “Evidence-based Complementary and Alternative Medicine” In this study, Polygonum multiflorum Radix promoted hair growth in mice, with oral administration being more effective, likely through FGF-7, while topical application favored SHH-related mechanisms.
23 citations
,
June 1999 in “Clinical Therapeutics” In this study, finasteride was found to reduce costs associated with benign prostatic hyperplasia compared to watchful waiting and terazosin, especially in men with higher prostate-specific antigen levels.
21 citations
,
November 2014 in “Journal of Endocrinological Investigation” This review discusses cross-sex hormone therapy for managing gender dysphoria in transsexual individuals and reports no new clinical results; it highlights the need for education and culturally sensitive training for healthcare professionals.