25 citations
,
April 2018 in “Electromagnetic biology and medicine” This study found that radiofrequency radiation from mobile phone use may increase DNA damage in hair follicle cells of the ear canal, with greater exposure duration linked to higher damage levels.
25 citations
,
January 2014 in “Annals of Dermatology” Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.
25 citations
,
April 2007 in “Journal of The American Academy of Dermatology” This article introduces the term "anisotrichosis" to describe the significant variation in hair shaft diameters observed in pattern alopecia, drawing a parallel to anisocytosis seen in blood smears, but reports no new research findings.
24 citations
,
March 2018 in “Pediatric Dermatology” This article addresses the complexity of treating acne in female-to-male transgender adolescents undergoing testosterone therapy, highlighting concerns about co-administered treatments and their potential risks.
24 citations
,
September 2005 in “Journal of Cellular Biochemistry” This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.
24 citations
,
April 2017 in “Aesthetic plastic surgery” In this study, micro-autologous fat transplantation (MAFT) for frontal augmentation using the MAFT-GUN showed high patient satisfaction and no complications among 178 patients, suggesting it may be a reliable method for forehead contouring.
24 citations
,
June 2012 in “BMC Research Notes” This study outlines the Human Gene Correlation Analysis tool, which classifies human genes by coexpression levels and identifies overrepresented annotation terms in correlated gene groups, with no new clinical results reported.
22 citations
,
January 2015 in “The Cochrane library” This review found no evidence that DHEA improves quality of life or decreases menopausal symptoms in peri- and postmenopausal women, but it may slightly enhance sexual function compared to placebo.
22 citations
,
March 2012 in “Molecular Medicine Reports” This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.
21 citations
,
October 2014 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This review discusses the role of hair dyes in cosmetic dermatology, their effects on hair and scalp health, and the importance of dermatologists understanding potential side effects; it reports no new findings.
21 citations
,
April 1998 in “Urology” This review summarizes a meta-analysis suggesting that finasteride is most effective for improving symptoms and urinary flow in men with large prostates experiencing benign prostatic hyperplasia.
20 citations
,
January 2016 in “Intractable & Rare Diseases Research” In this clinical experience, treating frontal fibrosing alopecia with oral finasteride, hydroxychloroquine, tacrolimus, and excimer laser was associated with optimal results in patients with active inflammation.
20 citations
,
September 2010 in “Cell Cycle” This study reports that in MRL mice, loss of p53 does not impair ear regeneration, suggesting p21's potential role in this process may involve the Tgfb/Smad pathway.
20 citations
,
January 2003 in “Journal of oleo science” This study found that both everyday physical and environmental stresses, as well as chemical treatments, contributed to hair damage, with cuticle layers being more noticeably affected.
19 citations
,
February 2007 in “International Clinical Psychopharmacology” This study provided the first published case reports of alopecia associated with the use of quetiapine.
19 citations
,
March 2003 in “Journal of Investigative Dermatology” This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.
19 citations
,
June 2002 in “American Journal of Dermatopathology” This study found significant differences in bcl-2 expression between areas of the scalp affected and unaffected by androgenetic alopecia, suggesting a uniform follicle population or synchronized follicular cycling in affected areas.
19 citations
,
December 1985 in “Journal of The American Academy of Dermatology” Minoxidil can cause scalp comedones and acne.
18 citations
,
February 2023 in “PLoS ONE” This study developed a triple drug delivery system using nanoparticles loaded with 5-fluorouracil, curcumin, and piperine to target breast tumors, demonstrating notable in vitro cytotoxicity and anti-metastatic potential in 3D tumor spheroids which suggests its promise for further preclinical evaluation.
18 citations
,
September 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that vitamin D-upregulated protein 1 (VDUP1) might play a unique role in regulating the differentiation of epidermal cells.
18 citations
,
January 2002 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” This study found that several new pregnane derivatives, especially steroids 16 and 19, demonstrated higher antiandrogenic activity on male hamster models than the commonly used finasteride.
17 citations
,
December 2009 in “Journal of Pediatric Orthopaedics” This report describes two cases of toe tourniquet syndrome in infants, highlighting the importance for pediatric orthopedic practitioners to diagnose and manage it promptly, suggesting a specific incision method to release hair strangulation if removal is challenging.
17 citations
,
April 2021 in “Molecules/Molecules online/Molecules annual” This study found that linoleic acid from Malva verticillata seed extracts may promote hair follicle cell growth and counteract hair loss signaling in a lab setting.
17 citations
,
May 2013 in “Oral and Maxillofacial Surgery Clinics of North America” This article reviews the complex challenges of managing scalp and cranial deformities post-trauma or surgery, advocating for better multidisciplinary approaches to enhance outcomes, but reports no new results.
17 citations
,
June 2012 in “European journal of medicinal chemistry” This study found that compounds 21–23 and 25 exhibited strong 5α-reductase II inhibition in vitro and significantly reduced rat prostate weight, performing comparably to finasteride.
17 citations
,
December 2004 in “Bioorganic & Medicinal Chemistry Letters” This study identified N-acyl arylsulfonamides, particularly N-(Boc-piperidine-4-carbonyl)-benzenesulfonamides, as steroid sulfatase inhibitors with improved cellular potency compared to previous compounds.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
16 citations
,
December 2016 in “Skin appendage disorders” This study analyzed patch test results to identify allergens causing scalp contact dermatitis, finding nickel, cobalt, and balsam of Peru among the most common in the patient population.
16 citations
,
January 2016 in “Annals of Dermatology” This study suggests that epigallocatechin gallate (EGCG) from green tea may counteract DHT-induced hair follicle damage by modifying the miRNA expression profile in human dermal papilla cells.
16 citations
,
July 2013 in “The American Journal of Dermatopathology” This study observed that pigmented casts are present in various alopecia types but are not specific to any single diagnosis, with distinct morphological features noted in trichotillomania.