32 citations
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January 2021 in “Molecules” This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.
64 citations
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March 2008 in “Neuropsychopharmacology”
27 citations
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December 2015 in “Clinical and Experimental Dermatology” This study found that hair regrowth occurred in 72.2% of alopecia areata patients treated with diphencyprone, with disease extent at baseline and duration affecting outcomes.
November 2021 in “Veterinary world/Veterinary World” In this study, dogs with localized demodicosis showed notable improvement in dermatological lesions when treated with Dipterocarpus alatus oil combined with Rhinacanthus nasutus leaf extract, particularly by day 28 of post-treatment, with no observed allergic reactions or clinical signs.
October 2025 in “Plant Science Today” This study found that cytokinin enhanced in vitro organogenesis, biological activities, and blooming in Vitex negundo, achieving a 100% shoot regeneration rate with specific cytokinin concentrations.
February 2018 in “The Journal of Sexual Medicine” In this animal study, finasteride exposure led to impaired spermatogenesis in rats, while the novel compound DA-9401, derived from three medicinal herbs, demonstrated potential in improving sperm parameters and reducing testicular apoptosis when used alone or with finasteride.
2 citations
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June 2018 in “Physiology & behavior” The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.
March 2016 in “The Journal of Urology” This historical review traces the discovery of 5-alpha reductase inhibitors, widely used in urology, from the study of guevedoces, Dominican children with a rare disorder leading to significant androgenization at puberty.
July 2025 in “Journal of Food Chemistry and Nanotechnology” This study explored the traditional uses of Trichosanthes cucumerina Linn., or snake gourd, highlighting its application in folk medicine across tropical and subtropical regions to address conditions such as fever, inflammation, digestive disorders, diabetes, and respiratory problems.
This review outlines the medicinal uses, phytochemical components, and pharmacological activities of the banana plant but presents no new experimental results.
This study found that the optimized AR antagonist compound 39 showed potent hair growth activity with improved safety in mice, suggesting potential for better topical treatments for androgenetic alopecia.
32 citations
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September 2010 in “Stress” This study found that suppressing allopregnanolone production in late gestation fetal sheep altered CNS activity and behavioral responses to transient asphyxia, effects mitigated by an analog co-infusion.
20 citations
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June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery” This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.
2 citations
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July 2015 in “Case Reports in Dermatology” In this case study, DDS treatment for LABD was complicated by hemolytic anemia and alopecia, suggesting the need for careful monitoring of these potential side effects.
1 citations
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January 2020 in “Indo global journal of pharmaceutical sciences” This article reviews the traditional uses of Citrullus colocynthis for various conditions like cancer and jaundice but reports no new clinical results, underscoring its role in folk medicine.
In this study, the researchers reported that the optimized compound 39 demonstrated potent AR antagonism and favorable pharmacokinetics in a hair-growth mouse model, achieving similar efficacy to pyrilutamide with faster onset and preserved safety, offering promise for next-generation topical AR antagonist development.
7 citations
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March 2023 in “Arabian Journal of Chemistry” This study suggests that cepharanthine may play an important role in treating SARS-CoV-2 infection by targeting multiple pathways and related targets associated with COVID-19.
22 citations
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November 2013 in “Clinical and experimental dermatology (Print)” This study suggests that Ecklonia cava, particularly its component dioxinodehydroeckol, may promote hair growth by enhancing dermal papilla and outer root sheath cell activity in culture and mice models.
This abstract lists numerous dermatological side effects and reactions associated with various medications but reports no new research findings.
September 2024 in “Frontiers in Neuroendocrinology” In this review, the researchers reported that 5α-reductase inhibitors demonstrated neuroprotective effects and reduced dyskinesias in animal models of Parkinson's disease, suggesting their potential for repurposing to manage symptoms in men with PD.
November 2025 in “Drug Testing and Analysis” This study investigated the metabolic pathways of epristeride, a new Type II 5α‐reductase inhibitor, using in vitro models and found that its metabolites show significant interactions with key proteins, suggesting implications for its role in doping control.
January 2009 in “Lishizhen Medicine and Materia Medica Research” The researchers reported that the aqueous extract of Urtica fissa E.Pritz inhibited 5α-reductase activity in vitro.
10 citations
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February 2017 in “European journal of neuroscience/EJN. European journal of neuroscience” This study found that local synthesis of 17β-estradiol and 5α-dihydrotestosterone, combined with specific stimulation patterns, is crucial in determining the direction and strength of long-term synaptic effects in the hippocampal CA1 region of male rat slices.
1 citations
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February 2023 in “Deleted Journal” This study found that Diphenylcyclopropenone (DCP) was effective for treating extensive alopecia areata in Thai patients, although a high relapse rate suggests maintenance therapy might be necessary.
20 citations
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October 2003 in “The Journal of Dermatology” This study observed that while dexamethasone-cyclophosphamide pulse therapy is relatively free from hypertension and diabetes compared to conventional steroids in pemphigus patients, it frequently causes generalized weakness and flushing.
January 2014 in “Journal of Pharmaceutical Negative Results” This study found that the ethanolic extracts of G. glabra and Z. mauritiana roots did not prevent androgenic alopecia in a testosterone-induced animal model.
1 citations
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June 2021 in “General physiology and biophysics” In this study, minoxidil-induced vasodilation in rat aorta was found to be mediated by ATP-sensitive potassium channels and nitric oxide pathways, but was not significantly altered by lipid emulsion pretreatment.
November 2022 in “PLANT ARCHIVES” This study reported on 23 medicinal plant species used in Ben M'hidi, El-Tarf, Algeria, providing ethnobotanical insights into their traditional therapeutic applications.
May 2021 in “Letters in Applied NanoBioScience” This study used computational methods to identify pranlukast and mirabegron as promising candidates for repurposing against diabetes due to their good binding interactions with the DPP-IV target.