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This study found that linoleic acid from Malva verticillata seed extracts may promote hair follicle cell growth and counteract hair loss signaling in a lab setting.

This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.

This study found that α-spinasterol treatment significantly reduced testosterone propionate-induced prostatic hyperplasia in rats, suggesting potential benefits for managing benign prostatic hyperplasia.

Male hormones control a specific gene in hamster skin, with different hormones having varying effects.

This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.

This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.

This study found elevated tissue levels of DKK-1 in patients with both androgenetic alopecia and alopecia areata compared to controls, suggesting DKK-1 as a potential therapeutic target for these conditions.

Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.

This study developed a DPC cell line by introducing mutant CDK4, Cyclin D1, and TERT, making it a promising tool to study downstream signaling pathways activated by testosterone in androgenetic alopecia.

This study found that KH053, combining Panax ginseng and bee-pollen, significantly reduced prostate weight and DHT levels, inhibiting BPH development in a rat model.

This study observed that the isotope-dilution GC-MS technique can assess 5α-reductase activity more effectively than conventional methods in rat liver S9 fractions, particularly at low testosterone levels.

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

UV light might cause excessive hair growth by increasing PGE2 in the skin.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.

This study found that exosomes derived from bovine colostrum promoted hair growth in mice by activating the Wnt/β-catenin pathway, with effects similar to minoxidil but without adverse effects.

Finasteride use may be linked to rare testicular tumor, but more research needed.

In this study, dihydroartemisinin reduced prostate enlargement and related markers in a rat model of benign prostatic hyperplasia, suggesting its potential as a therapeutic agent.

This study found that low androgen levels in rat penile endothelial cells were associated with a decrease in eNOS-expressing extracellular vesicles and reduced nitric oxide production.

In this study, researchers found that pregnant mice exposed to excessive androgen led to thinner ventricular walls and cardiac hypertrophy in offspring, suggesting that prenatal androgen exposure adversely affects cardiac health through reduced cardiomyocyte proliferation.

This study developed a high-throughput method that identifies bioactive chemicals influencing DHT production in prostate cancer cells, with potential nutraceutical candidates including fucoxanthin, phenethyl caffeate, and Curcuma longa L. extract.

This study found that host androgens like testosterone promote Staphylococcus aureus pathogenesis and skin infections by activating the agr quorum sensing system, revealing a mechanism for sex-dependent differences in these infections.

This study found that a sub-fraction of Noni fruit, FEA-3, showed hair growth-promoting effects in a rabbit model of androgenic alopecia, similar to Minoxidil.

This study found that dihydrotestosterone treatment in female rats altered anterior pituitary gland gene expression, with significant repression of prolactin and inhibition of GnRH receptor gene expression, suggesting specific hormone production changes.

In this study, a topical application of Lotus corniculatus seed extract significantly reduced sebum production and skin oiliness in humans through inhibition of lipid synthesis pathways.

This study found that platycodon ethanol extract showed potential as a natural ingredient for hair loss prevention by increasing radical scavenging ability, inhibiting inflammation, and affecting DHT generation in laboratory experiments.

This study found that Eucommia ulmoides bark extract shows potential antioxidant and hair follicle-support properties in vitro and in vivo, but further validation is needed to confirm these effects.

This study found that applying an ethanol extract of Prasiola japonica improved hair regrowth, length, and follicular density in testosterone-induced hair loss conditions in mice, while also promoting dermal papilla cell proliferation and reducing dihydrotestosterone production, though effects were less pronounced than those of minoxidil.

This study reports that perioperative use of dutasteride, both orally and through mesotherapy, may enhance hair graft survival and reduce shock loss in patients undergoing hair transplantation for androgenetic alopecia.

This systematic review discusses various topical, oral, injectable, and non-pharmacological treatments for androgenetic alopecia, examining both current and emerging therapeutic options in addressing this common form of hair loss.