2 citations
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January 2023 in “Research Square (Research Square)” This study found that obesity, insulin resistance, and hyperandrogenism increase the risk of depression and food cravings in women with PCOS, exacerbating obesity and metabolic syndrome.
2 citations
,
March 2004 in “Reviews in Gynaecological Practice” This review discusses treatments for female sexual dysfunction in postmenopausal women, noting that the effectiveness of current pharmaceutical options is inconclusive and emphasizing the importance of individualized care.
1 citations
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July 2015 in “Cambridge University Press eBooks” Testosterone therapy can improve sexual function in women but long-term safety is unclear.
March 2025 in “Journal of Endocrinology and Metabolism” This study found that while rat models treated with letrozole and dihydrotestosterone exhibit altered sterol, leukotriene, and steroid hormone profiles similar to human PCOS, significant differences remain.
This study found that metformin significantly improved clinical and hormonal indices in patients with polycystic ovary syndrome compared to pioglitazone, which also effectively controlled some symptoms.
January 2004 in “Online Publication Service of Würzburg University (Würzburg University)” This study found that women with PCOS displayed significantly higher activity of 5alpha-reductase, suggesting an additional role for liver and peripheral tissues in their androgen excess.
January 2004 in “Online Publication Service of Würzburg University (Würzburg University)” This study found that women with PCOS have higher activity of the enzyme 5alpha-reductase, which may contribute to their elevated androgen levels.
May 2026 in “Research Square” In this study of women aged 18-45 from an endocrine referral group, researchers found that while clinical hirsutism severity is independently associated with biochemical hyperandrogenism, the relationship is modest and suggests different biological aspects are at play.
January 1977 in “Case Reports in Medicine” This article discusses ovarian steroid cell tumors, which can produce testosterone and manifest symptoms like hirsutism, emphasizing surgery as the primary treatment, but reports no new clinical findings.
November 2025 in “Fertility Gynecology and Andrology” This study highlights that polycystic ovary syndrome develops through genetic and environmental factors, with insulin resistance as a key mechanism, impacting the risk of metabolic and cardiovascular conditions.
1 citations
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January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that hypothyroidism in women with PCOS significantly increased insulin resistance and obesity, which might worsen metabolic issues and impact conditions like hair loss and infertility.
138 citations
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July 2015 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses how Western diet may contribute to acne vulgaris through insulin signaling and metabolomic changes, promoting a dietary approach for management, but reports no new experimental results.
36 citations
,
January 2017 in “Journal of Obstetrics and Gynaecology Research” This review discusses the association between vitamin D receptor polymorphisms and polycystic ovary syndrome, noting the need for further research on their impact on the disorder's manifestations.
5 citations
,
August 2021 in “Frontiers in Cell and Developmental Biology” This study found that DHEA along with osteogenic induction medium significantly promotes the osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells from older individuals.
14 citations
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September 2023 in “Frontiers in Nutrition” This source observed that while supplementation with pro-, pre-, and synbiotics showed some beneficial effects for PCOS-related outcomes, the evidence quality was deemed low to very low, highlighting the need for further well-designed randomized controlled trials in women with PCOS.
3 citations
,
November 2024 in “Saudi Pharmaceutical Journal” This review highlights significant health risks associated with anabolic-androgenic steroid use in women and reports no new research results, emphasizing the need for further understanding of their effects on female physiology.
February 2024 in “Indian Dermatology Online Journal” This research highlights dermatologists' concerns about the widespread use of sports supplements, noting that nutritional supplements associated with muscle-building and appearance enhancement can lead to dermatological issues like acne and alopecia, while potentially containing harmful substances such as undisclosed anabolic steroids.
3 citations
,
August 2020 in “Nutrition Journal” This study found that spinach-derived thylakoid supplementation, combined with a calorie-restricted diet, led to more significant improvements in weight loss and insulin sensitivity in obese women with PCOS than calorie restriction alone.
September 2023 in “Clinical, Cosmetic and Investigational Dermatology” This study found a significant negative correlation between serum SHBG levels and androgenetic alopecia severity in women, but not in men, while no significant correlation was observed for testosterone, estradiol, dehydroepiandrosterone sulfate, and vitamin D levels with hair loss severity across genders.
December 2025 in “Neurobiology of Stress” This study found that individuals with a recent history of suicide attempts exhibited altered DHEA hair levels, suggesting possible dysregulation of the HPA axis as a biopsychosocial feature, and recommends further investigation into hair hormones as potential markers of suicidal crisis and vulnerability.
35 citations
,
January 2024 in “BioMolecular Concepts” This review discusses the relationship between oxidative stress and polycystic ovarian syndrome and reports no new clinical results; the authors emphasize the need for further research into therapeutic strategies.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.
September 2023 in “F&S reports” This review examines theories linking PCOS with psychiatric disorders, highlighting dietary interventions like probiotics and nutrients as possible improvements, but reports no new clinical findings and calls for more research.
September 2022 in “Polish Hyperbaric Research” This study analyzed 57 medicinal and cosmetic preparations available in Poland for treating alopecia, finding that finasteride is the most common active ingredient, with many products being in tablet or shampoo form and categorized as prescription drugs and cosmetics.
December 2020 in “Journal of Skin and Sexually Transmitted Diseases” This study found no significant correlation between serum testosterone or DHEAS levels and the severity of acne or FPHL in a localized female population, but noted most patients had low testosterone levels.
55 citations
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May 2019 in “Journal of Endocrinology” This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.
41 citations
,
June 2022 in “Biomedicines” This study proposes reclassifying PCOS into two distinct phenotypes based on androgen levels and suggests androgen supplementation may overcome IVF resistance in one group with advancing age.
2 citations
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August 2021 in “Experimental and Therapeutic Medicine” This study suggested that moxibustion treatment before or at the early stage of diminished ovarian reserve in rats may improve ovarian function by modulating androgen balance, though its effects differ across intervention timings.
1 citations
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July 2022 in “BMC Women s Health” This report describes a rare case of elevated serum DHEAS levels in a postmenopausal woman, linked to an ovarian sex cord-stromal tumor rather than the adrenal glands, challenging common assumptions about androgen sources.
2 citations
,
December 2022 in “Metabolites” This study found that progesterone levels were suppressed in underweight anorexia nervosa patients compared to healthy controls, as measured through hair analysis, and did not increase during short-term weight restoration.