Reconsidering the Polycystic Ovary Syndrome (PCOS)

    June 2022 in “ Biomedicines ”
    Norbert Gleicher, Sarah K. Darmon, Pasquale Patrizio, David H. Barad
    TLDR PCOS should be reclassified into two types based on hormone levels and symptoms.
    The document proposed a reclassification of Polycystic Ovary Syndrome (PCOS) into two phenotypes: a hyperandrogenic phenotype (H-PCOS) and a hyper-/hypoandrogenic phenotype (HH-PCOS). H-PCOS was associated with metabolic abnormalities, while HH-PCOS, which often developed hypoandrogenism after age 35, was linked to a hyperactive immune system due to autoimmunity and inflammation. The study suggested that HH-PCOS becomes resistant to in vitro fertilization (IVF) at this age, but androgen supplementation could overcome this resistance. The authors argued that polygenic risk scores could differentiate between these phenotypes, and at least one clustering analysis supported this reclassification.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 21 results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community Sugar and Hair loss connections

      in Research/Science  41 upvotes 6 months ago
      High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

      community C’est terrible - at my wits end

      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

    Related Research

    3 / 3 results