Changes in the PCOS Phenotype with Age

The document reviews how the phenotype of Polycystic Ovary Syndrome (PCOS) evolves with age, based on several studies. It indicates that younger women with PCOS generally exhibit higher androgen levels and lower BMI and insulin resistance, while older women tend to have increased insulin resistance and metabolic issues. A longitudinal study showed that over 20 years, androgen levels in women with PCOS decreased, waist circumference increased, and ovulatory cycles became more regular, suggesting a milder form of PCOS with age. However, metabolic abnormalities persisted or worsened. The prevalence of hyperandrogenism and oligomenorrhea in PCOS decreases with age, but obesity and metabolic disturbances become more common in older women. The document suggests that weight control in younger women with PCOS could mitigate the risk of later metabolic complications. The studies referenced include cross-sectional and longitudinal analyses, providing a detailed perspective on the age-related changes in PCOS.