Age-Specific Cut-Off Levels of Anti-Müllerian Hormone as Diagnostic Markers for Polycystic Ovary Syndrome

    May 2021 in “ Reproductive Biology and Endocrinology ”
    Fahimeh Ramezani Tehrani, Maryam Rahmati, Fatemeh Mahboobifard, Faezeh Firouzi, Nazanin Hashemi, Fereidoun Azizi
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    TLDR Different levels of anti-Müllerian hormone can help diagnose polycystic ovary syndrome in women of different ages.
    The study conducted by Ramezani Tehrani et al. included 803 women aged 20-40, with 303 diagnosed with PCOS and 500 as controls, and aimed to establish age-specific AMH cut-off levels for diagnosing PCOS. The research found optimal AMH cut-offs at ages 27 and 35, with levels of 5.7 ng/ml for ages 20-27, 4.55 ng/ml for ages 27-35, and 3.72 ng/ml for ages 35-40. High PPVs and NPVs were observed for these cut-offs, indicating their effectiveness in discriminating PCOS across different age categories. The study concludes that age-specific AMH levels can accurately assess the presence of PCOS in women of reproductive age, with the Bayesian method providing a reliable approach for determining these cut-offs.
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