Neuroendocrine, Neurotransmitter, and Gut Microbiota Imbalance Contributing to Potential Psychiatric Disorder Prevalence in PCOS

The document explores the complex interplay between neuroendocrine, neurotransmitter, and gut microbiota imbalances in contributing to psychiatric disorders in women with Polycystic Ovary Syndrome (PCOS). It highlights the roles of overactive hypothalamic-pituitary-ovarian and hypothalamic-pituitary-adrenal axes, abnormal neurotransmitter levels, and gut-brain axis dysfunction. Elevated androgens, cortisol, and altered gut microbiota are linked to psychiatric symptoms like depression and anxiety. Nutritional interventions, such as probiotics and micronutrient supplementation, show promise in alleviating these symptoms. The review underscores the need for further research to fully understand these mechanisms and their therapeutic potential.