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GlossaryHypothalamic-Pituitary-Adrenal Axis

regulates stress response through hormone release from brain and adrenal glands

The Hypothalamic-Pituitary-Adrenal (HPA) Axis is a complex network involving the hypothalamus, pituitary gland, and adrenal glands, which work together to regulate the body's response to stress. When you encounter stress, the hypothalamus releases corticotropin-releasing hormone (CRH), prompting the pituitary gland to secrete adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to produce cortisol, a key stress hormone. This system plays a crucial role in maintaining homeostasis and can impact various bodily functions, including immune response and metabolism.

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research Where Have the Periods Gone? The Evaluation and Management of Functional Hypothalamic Amenorrhea

18 citations , January 2020 in “Journal of Clinical Research in Pediatric Endocrinology”

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

research A Review of Hyperandrogenism State in Polycystic Ovarian Syndrome

November 2023 in “International journal of reproduction, contraception, obstetrics and gynecology”

Polycystic ovary syndrome causes high male hormone levels, leading to symptoms like excess hair, acne, and fertility problems.

research Ovarian Hormones and Adrenal Androgens During a Woman's Life Span

24 citations , September 2001 in “Journal of The American Academy of Dermatology”

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

research Anorexia Nervosa and Reproduction: Connecting Brain to Gonads

3 citations , April 2020 in “Journal of Mind and Medical Sciences”

Anorexia nervosa can harm fertility and increase pregnancy risks.

Neuroendocrine, Neurotransmitter, and Gut Microbiota Imbalance Contributing to Potential Psychiatric Disorder Prevalence in PCOS

research Neuroendocrine, Neurotransmitter, and Gut Microbiota Imbalance Contributing to Potential Psychiatric Disorder Prevalence in PCOS

September 2023 in “F&S reports”

PCOS may increase the risk of mental health issues like depression and anxiety.

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community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 5 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 1 year ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 2 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 17 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

in Treatment 43 upvotes 4 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

View more "hypothalamic-pituitary-ovarian axis" in community →