This study found that gels containing glycyrrhizic acid and aqueous Glycyrrhiza glabra extract significantly reduced underarm hair growth in terms of area, thickness, length, and number compared to their gel bases.
January 2016 in “Korean Journal of Pharmacognosy” This study found that Grateloupia elliptica extract may promote hair growth by activating wnt/b-catenin signaling and enhancing dermal papilla cell proliferation in rat and mouse models.
May 2015 in “Primary Dental Journal” The conclusion is that improved training and oversight for cosmetic procedures are recommended to better protect patients.
January 2006 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” This study found that Rubus coreanum extract promotes hair growth in mice, but its effects are not due to inhibition of specific enzymatic activities or growth factor expression.
August 1994 in “Toxicology in Vitro” This study standardized a reproducible three-dimensional human skin model for testing skin tumor promoters, using methods that do not require human skin sourcing.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inhibiting the interaction between HOTAIR and EZH2 can block pro-fibrotic gene expression in fibroblasts and interfere with tissue remodeling in systemic sclerosis patient skin.
April 2026 in “Frontiers in Cell and Developmental Biology” This study found that exosomes from human umbilical cord mesenchymal stem cells reduced hair follicle aging and promoted hair regeneration in models by upregulating COL17A1 through the miR-21-5p/DKK2/Wnt/β-catenin axis, outperforming existing treatments like minoxidil.
January 2026 in “Environmental Science and Pollution Research” In this study, oral administration of wheat sprout extract significantly protected rats against skin damage caused by acrylamide exposure by enhancing antioxidant defenses, reducing oxidative stress, and preserving skin structure, highlighting its potential as a sustainable protective agent against environmental skin toxins.
January 2026 in “RIGGS Journal of Artificial Intelligence and Digital Business” This study evaluated formulations of a cream containing turmeric and ginger extracts for inhibiting underarm hair growth, finding that the formulation with 15% stearic acid and 3% triethanolamine had the most optimal physical characteristics and potential for cosmetic development.
November 2025 in “Biomacromolecules” This research found that four types of biocompatible nanochitin promoted hair growth in mice, with partially deacetylated and phosphoric acid hydrolyzed nanochitins showing the best results, while amphoteric nanochitin provided the most balanced overall effect.
August 2024 in “Archives of Dermatological Research” This study suggests that proteins CHI3L1 and CXCL5, secreted by recovery-state dermal papilla cells, may promote hair growth by stimulating the proliferation of outer root sheath cells.
Low vitamin C caused bleeding and corkscrew hair, resolved with vitamin C treatment.
This study found that ocu-miR-205 promotes changes in signaling pathways and shifts in hair follicle phases, affecting Rex rabbit hair density by increasing secondary follicles.
September 2019 in “Journal of Investigative Dermatology” This study found that mosaic mutations in the CARD14 gene are linked to inflammatory linear verrucous epidermal naevus in two patients, who experienced significant improvement with the IL12/IL23 inhibitor Ustekinumab.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that JAK1 and JAK3 inhibitors effectively reversed alopecia in a mouse model of AA by reducing skin inflammation, while JAK2 inhibition did not promote hair regrowth.
September 2017 in “Journal of Investigative Dermatology” This study found that photodynamic therapy achieved permanent removal of nonpigmented hair in mice after multiple sessions, unlike laser treatment, which was not effective for nonpigmented hair.
June 2016 in “Experimental Dermatology” This study highlights the significance of SFRP2 expression in dermal papilla cells, noting its correlation with the inductive potential for hair growth, although its role may be more indicative than transformative.
April 2016 in “Journal of Investigative Dermatology” This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.
February 2016 in “Seoul National University Open Repository (Seoul National University)” This study found that photodynamic therapy may offer a new option for removing nonpigmented hair, although it was less effective than diode laser for black hair in mice.
March 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study suggests that novel lipid nanoparticle formulations may be suitable for delivering anti-alopecia compounds like minoxidil and finasteride, although their skin penetration was limited.
July 2013 in “International Society of Hair Restoration Surgery” This commentary explores the potential of 1α,25-dihydroxyvitamin D3 in enhancing hair regeneration by affecting dermal papilla cells, but reports no new experimental findings.
In this study, the n-hexane fraction of wheat bran significantly promoted hair growth in rat vibrissa follicles and triggered the telogen-anagen transition in C57BL/6 mice, likely through cell cycle and Wnt/β-catenin signaling pathways.
January 2012 in “ScholarlyCommons (University of Pennsylvania)” This study found that miRNA biogenesis, facilitated by Dicer and Drosha, is crucial for adult hair follicles' growth and regeneration, highlighting their multiple roles during the hair follicle growth cycle.
February 2010 in “Journal of the American Academy of Dermatology” Activating cAMP and ATP improves hair growth and strength.
January 2008 in “한국미용학회지” In this study, sandalwood and rose absolute oils were found to accelerate hair regrowth and promote hair follicle development in a mice model over four weeks.
January 2007 in “Pizhūhish va sāzandigī” This study describes the characteristics and potential research applications of the first hairless guinea pigs in Iran, noting their suitability for allergy, dermal, transplantation, and immunology studies.
December 2004 in “PLoS ONE” In this study, the Foxn1(-/-) nude phenotype was associated with an altered regulation of epithelial progeny in skin, offering a valuable model for investigating stem cell niche maintenance and regulation.
January 2020 in “Journal of Clinical Dermatology” This study found that oral dutasteride significantly increased hair density but not thickness in women with female-pattern hair loss, and identified a mechanism involving β-catenin activation.
January 2023 in “Cutaneous and Ocular Toxicology” This study found that ATP may help reduce ribociclib-induced skin damage in rats by mitigating biochemical changes associated with oxidative stress.
November 2022 in “Molecular Pharmaceutics” This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.