Original Article: Effect of Wheat Bran on Hair Growth

    January 2013 in “ 생약학회지
    강정일, 문정선, 김은지, 이영기, 고영상, 유은숙, 강희경, 임동술
    TLDR Wheat bran promotes hair growth by helping hair cells multiply.
    This study evaluated the effect of wheat bran on hair growth, finding that the n-hexane fraction of wheat bran significantly increased hair-fiber lengths in rat vibrissa follicles and induced the telogen-anagen transition in C57BL/6 mice. The fraction also promoted the proliferation of immortalized vibrissa dermal papilla cells (DPCs) in a dose-dependent manner. Molecular analysis revealed that this proliferation was associated with increased levels of cell cycle proteins (cyclin D1, cyclin E, phospho-CDK2, phospho-pRB) and Wnt/β-catenin signaling components (phospho(ser552)-β-catenin, phospho(ser675)-β-catenin, phospho(ser9)-GSK3β). These findings suggested that wheat bran could promote hair growth by regulating DPC proliferation through cell cycle proteins and Wnt/β-catenin signaling.
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