Nonpigmented Hair Removal Using Photodynamic Therapy

This study explored the use of photodynamic therapy (PDT) for removing nonpigmented hair, which traditional lasers cannot target. Using 7-week-old BALB/c mice, a photosensitizing cream was applied, followed by 630-nm light irradiation. Results showed a temporary catagen-like transformation in nonpigmented hair follicles, with anagen hair regenerating within 3 weeks. Molecular changes included increased levels of interleukin-6 and other markers post-PDT. While PDT achieved permanent nonpigmented hair removal on a small area after multiple sessions, it was less effective for black hair compared to an 800-nm diode laser. The study concluded that PDT could damage the nonpigmented hair matrix and might impair hair-regeneration capacity through effects on bulge stem cells or dermal papillae, suggesting PDT as a potential treatment for nonpigmented hair removal.